Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

PHARMACOLOGY 4.0 > Hypothalamic and Pituitary Hormones > Flashcards

Hypothalamic and Pituitary Hormones Flashcards

1
Q

Alternative to Gonadotropin treatment in Male infertility

A

Gonadorelins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Antagonist for Oxytocin receptor

A

Atosiban

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is a contraindication to GH therapy?

A

Patient with Malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Treatment of Leiomyomata (Fibroids)

A

continouos GnRH agonists + supplemental iron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ADR that is characterized by Serum testosterone levels increase (first 7-10 days; falls about 2 weeks) precipitate pain in patients with bone metastases, and tumor growth and neurologic symptoms

A

Tumor flare

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Contraindications to Oxytocin treatment

A

Fetal distress abnormal fetal presentation cephalopelvic disproportion uterine rupture Prematurity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

a disease of GH receptor insensitivity

A

Laron syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ERGOT DERIVATIVE Dopamine Agonist

A

Bromocriptine Cabergolide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

role of continuous GnRH and GnRH analog in COH

A

prevent pemature LH surge and ovulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Vasopressin Antagonists

A

Conivaptan Tolvaptan (more V2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Treatment of Choice for central precocious Puberty

A

GnRH analogs: Leuprolide Nafarelin Histrelin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Growth Hormone Antagonists

A

o Somatostatin o Somatotropin-Release Inhibiting Factor o Dopamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Measures the fetal heart rate response to a standardized oxytocin infusion; Provides information about Placental Circulatory Reserve

A

Oxytocin Challenge Test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Advantage of GnRH antagonists over GnRH analogs

A

Immediate antagonist effect effects reverse more quickly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

acetate salt of synthetic human GnRH

A

Gonadorelin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Major source of IGF-1

A

liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

hCG is produced and excreted where?

A

produced: placenta excreted: urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Patients with Turner’s who are taking GH therapy are prone to development of

A

Otitis media

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

3 forms of purified FSH

A

Urofollitropin (2) recombinant forms: Follitropin alfa Follitropin beta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Alternative for Ovulation induction (ex: Clomiphene has no effect)

A

gonadotropins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Treatment of severe IGF-1 deficiency that is not responsive to GH (GH-resistance syndromes)

A

Mecasermin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Peripheral antagonism of GH: decreases IGF

A

Pegvisomant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

GnRH receptor antagonists:

A

Ganirelix Cetrorelix Abarelix Degarelix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Treatment for Tumor flare?

A

Bicalutamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Menotropin that is purified (removed LH function)
Urofollitropin
20
what does it mean when Administration of GnRH has No change in baseline serum LH
Hypogonadotropic Hypogonadism or Constitutional Delay
21
human menopausal gonadotropin extracted from urine of menopausal women
Menotropins
22
Treatment for endomtriosis
continouos GnRH agonists: Leuprolide Goserelin Nafarelin (nasal spray)
23
Side effects of Pegvisomant
o Reversible liver enzyme elevation o Lipodystrophy o Injection site pain
24
early sign of GH deficiency
Hypoglycemia
25
Contraindications of GnRH Therapy
Pregnancy Lactation
26
drug that is packaged and dosed at the basis of its weight rather than its activity
Choriogonadotropin alfa (rhCG)
26
Risks of Controlled Ovarian Hyperstimulation in ART
o Multiple pregnancies o Ovarian hyperstimulation syndrome (OHSS)
27
rarely reported adverse effect of GH therapy (may manifest as vision changes, headache, nausea, or vomiting)
Intracranial hypertension (Pseudotumor Cerebri)
29
used for stimulation of follicular development in infertile women with profound LH deficiency
Lutropin alfa
31
Recombinant form of GH
Somatropin
32
hCG is virtually identical to what 3 other hormones
TSH, LH, FSH
33
stimulates the release of prostaglandins and leukotrienes that augment uterine contraction
Oxytocin
34
Mecasermin is composed of?
o rhlGF-1 (recombinant human IGF) o rhlGFBP-3 (binding protein-3)
35
Treatment regimen for prostate cancer
continouos GnRH agonists + Androgen receptor antagonist (Flutamide)
37
Treatment for Male infertility and for ART
hCG
40
Ergot-derivative Dopamine agonist with longest duration
Cabergolide
41
Functions of FSH in males and females
females: stimulates granulosa cells to convert androgens to estrogens Males: stimulates sertoli cells to convert testosterone to estrogen
42
Synthetic analogs of GnRH
 Goserelin/LHRH  Histreln  Leuprolide  Nafarelin  Triptorelin
43
Principal Function is for ovarian follicle development
FSH
44
Gonadotropins are most commonly used for what condition?
Controlled Ovarian Hyperstimulation
46
Function of LH in males and females
females: stimulates theca cells for androgen production males: stimulates leydig cells for testosterone production
47
45x more potent in inhibiting GH release (compared to Somatostatin)
Octreotide
48
DOC for acromegaly
LANREOTIDE
50
Cornerstone of Assisted Reproductive Technology
Gonadotropins (FSH, LH, hCG)
51
Treatment of Choice for Female infertility
Clomiphene
52
Stimulates longitudinal bone growth until epiphyses close near the end of puberty
IGF-1
53
Toxicity of Dopamine Agonits
Erythromelalgia Peripheral digital vasospasm Psychiatric manifestations
54
Standard medical treatment for hyperprolactinemia
Dopamine agonists
55
NON-ERGOT DERIVATIVE Dopamine Agonist
Quinagolide Pramipexole Ropinirole
56
Biphasic response to continous gonadorelin treatment
Flare (first 7-10 days) Receptor-down regulation
57
Long-acting synthetic analog of vasopressin
Desmopressin acetate
58
Treatment for Tocolysis (preterm labor)
Atosiban
59
What is the most important adverse effect of Mecasermin?
Hypoglycemia
60
Most widely used somatostatin analog
Octreotide
61
2x more potent in reducing insulin secretion (compared to Somatostatin)
Octreotide

PHARMACOLOGY 4.0 (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions