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PHARMACOLOGY 4.0 > Adrenal Hormones > Flashcards

Adrenal Hormones Flashcards

1
Q

Adrenal suppression manifests after how long of corticosteroid therapy

A

> 2 weeks

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1
Q

Progestin in oral contraceptive; aldosterone antagonist

A

Drospirenone

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2
Q

Diagnostic test for Cushing’s syndrome

A

Dexamethasone Suppression Test

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3
Q

1/3 of cortisol produced daily is excreted in the urine as

A

dihydroxyketone metabolites

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4
Q

enzyme that converts cortisol to cortisone

A

11-hydroxysteroid dehydrogenase

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4
Q

Potent steroid with both glucocorticoid and mineralocorticoid activity

A

Fludrocortisone

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4
Q

used diagnostically for detection of aldosteronism in hypokalemic patients with hypertension dosage of 400-500 mg/d for 4-8 days

A

Spironolactone

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5
Q

Approved for treatment of hypertension; spironolactone antagonist

A

Epleronone

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6
Q

Treatment for Aldosteronism

A

Fludrocortisone Deoxycorticosterone acetate

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8
Q

major limitation in the treatment use of glucocorticoids

A

Osteoporosis

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8
Q

Causes generalized glucocorticoid resistance

A

MIfepristone

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9
Q

What is present if 17-hydroxylation in the adrenals is defective?

A

Hypogonadism

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9
Q

Precursor of aldosterone, half life

A

Deoxycorticosterone, 70 mins

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11
Q

Half life of Cortisol

A

60-90 minutes

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12
Q

Excessive production of aldosterone by adrenal adenoma

A

Primary Aldosteronism

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14
Q

Treatment for Congenital Adrenal Hyperplasia

A

Oral Hydrocortisone

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15
Q

Glucocorticoid antagonists

A

MAKAMTM Metyrapone Aminogluthetimide Ketoconazole Abiraterone Mifepristone Trilostane Mitotane

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16
Q

a 3β-17 hydroxysteroid dehydrogenase inhibitor

A

Trilostane

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17
Q

Drug of choice for stimulation of lung maturation in fetus

A

IM Bethamethasone (mother)

18
Q

Ketoconazole ADR

A

Hepatotoxic

19
Q

Relative selective inhibitor of 11 hydroxylation, interfering with cortisol and corticosterone synthesis

A

Metyrapone

19
Q

Reduces synthesis of corticosteroids in the gonads

A

Abiraterone

21
Q

excreted cortisol in the urine is measured by

A

17-hydroxysteroids

21
Q

Treatment of Hirsutism in women

A

Spironolactone (50-200mg/d)

22
Treatment for Addison's Disease
Large amount of parenteral hydrocortisone + correction of fluid and electrolyte abnormalities
22
Low suppressed levels of plasma renin activity & angiotensin II
Secondary Aldosteronism
23
what is the daily hydrocorticosteroid levels in Addison's Disease?
20-30 mg
23
Blocks 17ά-hydroxylase and 17,20-lyase
Abiraterone
26
Most commonly prescribed salt retaining hormone
Fludrocortisone
27
Used in conjunction with dexamethasone or hydrocortisone (eliminate estrogen production in breast CA)
Aminogluthetimide
28
Normal individual morning cortisol
\< 3 mcg/dl
29
An orally active prodrug and has been studied in the treatment of refractory prostate cancer.
Abiraterone
30
Related to the DDT class of insecticides
Mitotane
31
Used in treatment of Primary Aldosteronism with dosage of 50-100mg/d
Spironolactone
33
large amounts of deoxycorticosterone is produced when this adrenocortical enzyme is deficient
11-hydroxylase
34
Treatment for Cushing's Syndrome
surgical removal of the tumor resection of the adrenals given with 300mg soluble hydrocortisone as continuous IV on the day of surgery
35
Block conversion of cholesterol to pregnenolone
Aminogluthetimide
36
half life of aldosterone
15 -20 minutes
38
Daily dose of 100 mg hydrocortisone or more , for \> 2 weeks produces?
Iatrogenic Cushing's Syndrome
39
Potent and rather nonselective inhibitor of adrenal and gonadal steroid synthesis
Ketoconazole
40
what is the source of synthetic corticosteroids?
Cholic acid
41
Result of bilateral adrenal hyperplasia secondary to an ACTH –secreting pituitary adenoma
Cushing's syndrome
43
How to differentiate between Hypercortisolism due to anxiety and alcoholism
Dexamethasone for 2 days and then followedby CRH test
44
rare but serious acute adverse effects of high dose glucocorticoids
Acute pancreatitis
45
Mineralocorticoid antagonist
SPIRONOLACTONE

PHARMACOLOGY 4.0 (3 decks)

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