Hypoglycaemia Flashcards
What are causes of hypoglycaemia in a diabetic patient?
Insulin or sulphonylurea use plus other factors:
- Exercise
- Missed meal
- Overdose
What are causes of hypoglycaemia in non-diabetic patients?
- Exogenous drugs
- Pituitary insufficiency
- Liver failure
- Addison’s disease
- Islet cell tumours
- Non-pancreatic neoplasms
What are examples of exogenous drugs which can cause hypoglycaemia?
- Insulin
- Alcohol use
- Aspirin poisoning
- ACE-i
- B-blockers
- IGF-1
- Pentamidine
What are the main symptom/sign groupings of hypoglycaemia?
- Autonomic syptoms/signs
- Neuroglycopenic symptoms/signs
What are the autonomic features of hypoglycaemia?
- Sweating
- Anxiety
- Hunger
- Tremor
- Palpitations
- Dizziness
What a neuroglycopenic features of hypoglycaemia?
- Confusion/Irritability
- Drowsiness
- Visual trouble
- Seizures
- Coma
- Focal features - rare
What is the definition of hypoglycaemia?
BG of <3 mmol/L
What investigation would you do in someone with suspected hypoglycaemia?
Blood glucose - most important test
- Cap glucose
- Lab glucose
Consider tests for suspected cause
- LFTs
- Addison’s test
- Insulin levels
- C-peptide
- Proinsulin
When interpreting results, what could cause hypoglycaemic hyperinsulinaemia?
- Insulinoma
- Sulphonylurea
- Insulin injection
- Mutation of insulin receptor gene
How could you tell if someone with hypoglycaemia had taken injectable insulin overdose based on blood results?
No c-peptide present in the blood, but hyperinsulinaemia
How would you manage mild hypoglycaemia?
15-20g quick acting carbohydrates
5-7 dextrose tablets/4-5 glucotabs
OR
170-220 mls original lucozade
OR
150-200 mls pure fruit juice
If someone had low insulin and high ketones and had hypoglycaemia, what could be the cause?
- Alcohol
- Pituitary insufficiency
- Addison’s Disease
When would you consider giving further treatment for mild hypoglycaemia?
If BG is <4 mmol/L after 15 minutes of giving 15-20g quick acting carbohydrates, repeat initial management up to 3 times
If after treating someone repeatedly for mild hypoglycaemia with oral carbohydrate solutions, what would you consider?
IV 10% glucose - 100 ml/hr
OR
1 mg Glucagon IM
How would you manage moderate hypoglycaemia?
If capable/cooperative - same as mild hypoglycaemia treatment
If not capable/cooperative
- 1.5-2 tubes glucogel
If ineffective - 1mg Glucagon IM
If, after giving repeated treatments with glucogel (or 1 mg glucagon) for moderate hypoglycaemia, what would you consider giving?
IV 10% glucose at 100 ml/hr
How would you manage someone with severe hypoglycaemia?
- Check ABC
- Stop IV insulin
- Give 75 ml IV 20% glucose OR 1mg Glucagon IM
How soon after giving treatment for severe hypoglycaemia would you recheck someones blood glucose?
10 minutes
What would you give someone who’s blood sugar (after treating them initially) was above 4 mmol/L?
20g long acting carbs
- Two biscuits
- Slice of bread
- 200-300 ml milk
If IM glucagon used - use 40 g long acting carbs
If someone was nil by mouth after getting their blood glucose above 4 mmol/L, how would you manage them?
IV 10% glucose - 100 ml/hr
What dose of glucagon is used to treat hypoglycaemia?
1mg
How is glucagon administered?
IM
What rate would you give someone IV 10% glucose to treat unresponsive mild/moderate hypoglycaemia?
100 mls/hr
What volume of IV 20% glucose would you give someone with severe hypoglycaemia (unconscious patient)?
75ml 20% glucose
What volume of IV 10% glucose would you give someone with severe hypoglycaemia (unconscious patient)?
150ml 10% glucose
What rate should IV glucose be given at in severe/unresponsive hypoglycaemia?
IV STAT
When may glucagon be ineffective?
- In severe liver disease
- Undernourished patients
How might having given glucagon influence subsequent management with long acting carbohydrates once blood glucose levels begin to rise?
40g long acting carbs, not 20g
