Hypo-Pit-Gon Flashcards
Where GnRH cell bodies found?
arcuate nucleus- infundibular nucleus
Where do GnRH cell bodies project to?
median emminence
How is kisspeptin expression regulated?
by gonadal steroids
What is quality of kisspeptin for experiments?
Most efficient at the BBB
Cheaper to make in research
What do inactivating mutations of Kisspeptin result in?
failure to undergo spontaneous puberty
What can activating KISS1R mutations lead to?
precocious puberty
What does a bolus injection in mice result in?
peak in LH secretion
How can GnRH levels be measured?
LH levels are used as an indication of GnRH
How is GnRH secreted?
pulsatile
Where are the pulse generators for GnRH secretion?
neurons in the hypothalamus
Describe GnRH structure
Includes GAP
How often is GnRH secreted?
pulses from hypothalamus every 30-120min
What does slow GnRH secretion favour?
FSH beta transcription
What does rapid pulse frequency favour?
LH beta transcription
Which neurons are responsible for the pulsatile secretion of LH?
ARNKISS were all found to exhibit intermittent periods of synchronized electrical activity which had a near perfect correlation with pulsatile LH secretion.
Where are ARNKISS found?
mid-caudal region of the arcuate nucleus
Which part of LH and FSH and hCG is common
alpha unit
What bonds hold the alpha and beta components together in gonadotrophs?
disulphide
What other groups can be found on alpha and beta components of gonadotrophs?
glycolylations
Which part of gonadotrophs receptors are prone to mutations?
extracellular part
What are the functions of FSH in testes?
regulation of Sertoli cell metabolism
What are the functions of FSH in ovaries?
- follicular maturation
- granulosa cell estrogen synthesis
What are the functions of LH in tetes?
- stimulation of Leydig cell androgen synthesis
What are the functions of LH in ovaries?
theca cell androgen synthesis
- ovulation
- progesterone production of corpus luteum
