hypertensive disorders of pregnancy Flashcards
4 HTN disorders of pregnancy
-chronic HTN
-gestational HTN
-chronic HTN w superimposed preeclampsia
-preeclampsia/eclampsia
elevated BP that predates pregnancy
chronic HTN
what normal Tx for chronic HTN are not recommended in pregnancy (2)
-weight loss
-extremely low sodium diets
who is at risk for chronic HTN
-advanced maternal age
-obesity
-lack of exercise
-comorbidities
-diabetes
-smoking
meds you can’t use to treat HTN during pregnancy
ACE inhibitors
med to treat HTN during pregnancy (3)
-b blocker (labetalol)
contraindicated in pts with HF or asthma
-CCB (nifedipine)
-methyldopa
blood pressure elevation after 20 weeks of gestation (in absence of proteinuria and other features preeclampsia)
gestational HTN
what is considered proteinuria
-protein/creatinine ratio 0.3mg/dL (more than +1)
-300 mg or more of protein in 24 hr urine
what bp is treated during pregnancy
160/110
(or Sbp +30/Dbp +15 over baseline)
what happens with preeclampsia (patho)
-constricted spiral arteries to placenta
-vasospasms (endothelial damage)
-decreased maternal CO (impaired blood flow to organs)
-hypovolemia
-platelet aggregation that further constrict spiral arteries
-decreased tissue perfusion, increased cellular hypoxia
preeclampsia diagnostic criteria (2)
-bp 140/90
-protein/Cr ration >0.3 or >300 mg in 24 hr urine
(+edema, thrombocytopenia)
risk factors preeclampsia
-genetic
-multiples
->35 yo or teenagers
-diabetes
-obesity
-preexisting HTN/renal disease
-Hx of thrombophilia
-IVF
-SLE (autoimmune disorders)
severe features of preeclampsia (7)
elevated BP + atleast one feature = severe
-Sbp >160
-Dbp >110
-thrombocytopenia (plt <100)
-impaired liver function (severe RUQ pain, unresponse to meds)
-progressive renal insufficiency (Cr>1.1)
-pulmonary edema
-new onset cerebral/visual disturbances (headache, blurred vision)
complications severe preeclampsia
-pulmonary edema
-MI
-stroke
-acute resp distress
-coagulopathy (DIC)
-severe renal failure
-retinal injury
-abruption
diagnosis of superimposed preeclampsia (with women who had chronic HTN)
-sudden exacerbation HTN (previously well controlled)
-sudden onset S+S (headache, blurred vision)
-Plt >100
-development pulmonary congestion/edema
-development renal insufficiency
-sudden/sustained protein increase (proteinuria)
what value is considered thrombocytopenia
plt >100,000
prenatal pt care for HTN disorders
-daily assessment of symptoms
-daily fetal kick counts
-serial assessments bp (atleast 2x weekly)
-labs weekly (platelets, liver enzymes)
-ultrasound to assess fetal growth
-antenatal steroids (accelerates fetal lung maturity)
PRES
what does it stand for and what is it
posterior reversible encephalopathy syndrome
= swelling of brain caused by HTN crisis, leads to seizures
how to elicit clonus
sharp dorsiflexion of foot
clonus = shaking of foot
med to protect from seizures with preeclampsia
magnesium sulfate
smooth muscle relaxer
when do you worry about creatinine in pregnancy
> 1.1