Hypertension medication Flashcards
Blood pressure formula?
Blood pressure = cardiac output x vascular resistance
What is systolic and what is diastolic?
systolic - when the heart contracts (120), diastolic - when the heart relaxes (80)
What is cardiac output?
the amount of blood leaving the heart per minute
How can cardiac output be altered?
heart rate (speed), the volume it ejects with each contraction
What is vascular resistance?
There is total, peripheral and central, and it is the resistance that the blood encounters as it travels through the blood stream
How can vascular resistance be altered?
size of vessels (dilate or constrict), thickness of blood (number of blood cells, severe dehydration), length of vessels
Factors causing elevated BP?
elevated cardiac output or increased resistance in the blood vessels?
What blood pressure medications are there?
AAAABCD
they can work by addressing the cardiac output or vascular resistance or both
What are the groups of blood pressure medications?
AAAABCD
Alpha-1-Blockers, ACE inhibitors, Angiotensin-2-Receptor Blockers, Aldosterone Blocker’s, Beta Blockers, Calcium Channel Blockers, Diuretics
Alpha-1 Antagonists / Blockers
the -Osins : Prazosin, Doxazosin, Terazosin
they BLOCK alpha-1 -> dilating effect on blood vessels with Alpha 1 receptors -> decreased resistance -> decreased BP
not commonly used
The Androgenic System - Adrenaline
fight/flight response, adrenaline
Alpha 1 and Beta 1 Receptors: when bind with noradrenaline they stimulate cells to DO their function; Alpha 2 and Beta 2 Receptors: triggers them to STOP their function
Adrenergic receptors, generally located on blood vessels, if noradrenaline binds it causes the vessels to constrict
The Androgenic System - Noradrenaline
Sympathetic response, noradrenaline
Alpha 1 receptors: stimulating smooth vessels on blood vessels -> constrict -> narrow diameter -> increased vascular resistance -> increased BP
Alpha 1 Blockers - Side effects
postural hypotension, stress incontinence (laughing, sneezing)
What group of hypertension medication ends in -osin (prazosin, doxazosin, terazosin)
Alpha 1 Blockers / Antagonists
ACE inhibitors
the -prils : ramipril, lisinopril, enalapril, perindopril
work on the kidneys, specifically the renin-angiotensin system (inhibiting ACE) -> no Angiotensin II is made -> no other processes occur to raise BP
also appear more effective at kidney, brain and heart, plus an effect of increased bradykinin release (vasodilator)
Importance and role of the Renin-Angiotensin-Aldosterone System
kidneys need to filter 1L of blood per minute to maintain GFR, if the volume drops, the kidneys won’t filter properly, renin-angiotensin system is activated when the volume drops