Hypertension Flashcards
what is Normal BP range?
Systolic under 120 Diastolic under 80
what range is considered elevated BP?
Systolic 120-129 Diastolic <80
what range is considered Stage 1 Hypertension?
Systolic 130-139 Diastolic 80-89
what range is considered Stage 2 Hypertension?
Systolic 140 and over Diastolic 90 and over
what range is considered a hypertensive crisis?
Systolic over 180 and diastolic over 120
What is primary/essential hypertension?
Hypertension that we do not know the specific cause of, however it is usually correlated to lifestyle factors and genetics. 90-95% of all adults diagnosed with HTN have primary hypertension.
What is secondary hypertension?
Hypertension where we can pinpoint the cause. Some causes are chronic kidney disease, polycystic kidney disease , renal artery stenosis. There are also endocrine causes such as Cushing’s disease, hyperaldosteronism, hyperparathyroidism, and pheochromocytoma. 5-10% of adults diagnoses with HTN fall within this category.
How does NSAIDs increase BP?
By retaining salt.
Why does NSAIDs constrict the efferent arterioles?
Because they break down prostaglandin which is a vasodilator. The vasoconstriction will activate the RAAS which will increase BP.
what part of the body produces nitric oxide?
The endothelium cells which is the inner lining of the blood vessels.
What is nitric oxide?
A vasodilator.
What happens to the blood vessels when a person is sufferings from HTN?
The inner lining gets damaged over time and plague or cholesterol builds up which makes the vessel narrow. Also damaged endothelium will no longer produce nitric oxide which is a vasodilator and the vessels will vasoconstrict.
How does Cushing’s disease increase BP?
increases cortisol, glucocorticoids and mineralocorticoids (stress). Constant alarm stage which becomes chronic stress and BP will increase.
How does Hyperparathyroidism increase BP?
Calcium – takes calcium from bone and increases levels of calcium in blood. Calcium affects the muscles by contracting them. Which will increase BP
How does Hypoparathyroidism increase BP?
Patients with Hypoparathyroidism often struggle with lethargy, and are not using the sugar and fats through diet for energy, there will be increase in cholesterol which will increase BP.
How does Prostate disease cuase increased BP?
Due to urinary retention and therefore increase in BP.
What other diseases/conditions may prolonged hypertension lead to?
Inflammation in the endothelium which causes atherosclerotic disease which may contribute to an MI, Cerebrovascular accident and kidney disease due to narrowing of vessels.
Damaged endothelium walls makes it easier for cholesterol to attach to the walls which makes the blood vessels more narrow. This may cause chest pain, angina, MI, cerebrovascular accident (stroke), blindness may happen due to damaged blood vessels in the eyes.
For older adults what is the target blood pressure?
Less than 130 over 80
why do we want to start low and go slow when it comes to giving older adult antihypertensive medications?
Because they are at greater risk of orthostatic hypotension whihc may increase the risk of falls. It is harder for older adults to adapt to a change in BP.
In terms of blood vessels what increases BP?
BP rises due to increased vascular resistance (blood vessel constriction) and elevated cardiac output (blood volume pumped).
How come increase in sympathetic nervous system activity increases BP?
Because epinephrine released by the SNS increases BP.
How does insulin resistance increase BP?
Insulin resistance raises BP as glucose remains in the bloodstream, leading to vessel inflammation and damage.
This damage encourages cholesterol buildup and platelet aggregation, narrowing the vessel lumen and restricting oxygenated blood flow.
How does immune system activation increase BP?
Inflammatory processes activate the immune system, placing the body under constant stress, which in turn increases BP.
Why is advancing age a risk factor for HTN?
Decreased elasticity of the vessels. Heart has to pump harder. there are also co-morbidities.