Hypertension Flashcards
What does hypertension mean?
High blood pressure
As blood pressure increases so does the risk of? (5)
Myocardial infarction
Heart failure
Stroke
Renal disease
retinopathy
Hypertension effects about what percentage of United state adults?
46%
What is hypertension management??
What are the 2 target goals
Target goals are based on
Age & comorbidities
Who has the highest risk of hypertension?
Race & gender
Black people
Female
Black people have less of response to what?
And why does this effect them on getting angioedema?
Renin inhibiting medication
Because we want to stop our reninfrom our kidneys from sodium/fluid retention but since they have less response to the actual medication to renin it’s hard
Black people are at increased risk of what?
And how does that work?
Angioedema with ACE inhibitors
( Angiotensin converting enzyme)
The whole point of the the renin system is to sodium/fluid retention but since the ACE inhibitor is going to double that retention, we are going to cause edema ( swelling )
Which race group is less likely to receive treatment?
Hispanics
Hypertension is more common on men before the age of what?
Before middle age
Women have a higher risk of getting hypertension how (3)?
Oral contraceptives
Preeclampsia
After menopause
What does blood pressure mean ?
Force exerted by blood against walls of blood vessels
What is the blood pressure function ?
Cardiac output and systemic vascular resistance
What is the formula for BP?
CO = SV x HR
cardiac output = stroke volume X heart rate
How does the sympathetic nervous system effect our blood pressure?
It increased what 6 things?
CHII!!!
Cardiac contractility within seconds
Heart Rate
Increase Cardiac output
Increase systemic vascular resistance
Renin release
Vasoconstriction
How does Parasympathetic effect blood pressure? (3)
It does what to your blood pressure?
It decreases your heart rate ( vagus nerve )
Decrease Cardic output
Decrease BP
Sympathetic causes what?
What happens to pupils?
What happens to saliva?
What happens to heart beat?
What happens to airways?
What happens to digestion?
What happened to liver?
What happens to intensities?
Also secrete what??
What happens to bladder?
Dilate pupils
Inhibit salivation
Increase heartbeat
Relax airways
Inhibit stomach activity
Inhibit gallbladder
Inhibit Activity intensities
Secrete epinephrine/adrenaline
Relaxes bladder
Parasympathetic
What happens to pupils?
What happens to saliva?
What happens to heart beat?
What happens to airways?
What happens to digestion?
What happened to liver?
What happens to intensities?
What happens to bladder?
Constrict pupils
Stimulate salvia
Slow heartbeat
Constrict airways
Stimulate stomach
Stimulate gallbladder
Stimulate intestines
Contract bladder
What are the 5 sns receptors that effect blood pressure?
A1
a2
B1
B2
Dopamine
How does A1 receptor effect blood pressure?
Vasoconstriction
Increased contractility
( positive inotropic ; contraction )
How does A2 sns receptors affect blood pressure?
And explain the process of this?
Inhibit release of norepinephrine
When there isn’t a release of nonreponephrine, the blood pressure will drop
How does B1 sns affect blood pressure?
Increase contractility
Heart rate ( Chronotropic )
Conduction
What is the B2 sns affect receptor mean for Blood pressure?
Vasodilation
What does dopamine do for sns receptor affecting blood pressure?
Vasodilator
Where are baroreceptors located?
Carotids and aortic arch
Baroreceptors are sensitive to what and what happens to our blood pressure?
Sensitive to stretching which happened with increased blood pressure
What are the function of Baroreceptors ?
Monitor how much blood you have your blood vessels and fixing it to have a normal BP
When the Baroreceptors notice a low blood pressure what does it do?
Activates the SNS
And increase heart rate etc
When Baroreceptors detect a high blood pressure it’s going to do what?
Sending inhibitor impulse’s sympathetic nervous system
( Pretty much to stop SNS impulses from happening )
When the Baroreceptors send inhibitory impulses sns ? What does it cause? (3)
Decreased heart rate
Decreased force of cardiac contraction
Increased vasodilation of arterioles
( pretty much stopping sns impulses to happen and focus on psn )
When you have chronic hypertension what does that cause to Baroreceptors?
To reset baseline
( pretty much hypertensive state is there new normal, so like 130/90 is there new normal BP and the Baroreceptors don’t detect a need to change )
What are 3 factors that influence blood pressure?
Vascular endothelium
Renal system
Heart cells : natriuretic peptides : ANP/BNP
How does vascular endothelium affect blood pressure?
What will it produce in order to maintain?
It produces vasoactive substances to maintain low arterial tone
Explain how vascular endothelium effects blood pressure
Along side the blood vessel, there are endothelium cells
These endothelium cells are regulated by our vascular tone
However when we have hypertension these endothelium cells are distrusted and causes vasocative substances to be released and causes our body to constrict
Since the whole job of a vascular tone is to help with constriction of blood vessel to allow blood to come, but if we have high blood pressure we are going to constrict even more and not let that blood flow come in
Causing that low arterial tone
Meaning not all the blood is being pushed through, just bit by bit cause of that constriction
Not only does vascular endothelium cells effect our blood pressure but if we (2) it also effects the elasticity of vessels
Think of which diseases
Smoke
Diabetic mellitus
How does our renal system effect our blood pressure? (3)
Controls sodium excretion & extracellular fluid volume
Renin system
Prostaglandins - vasodilators
How does the control sodium excretion and ECF from the renal system effect our blood pressure?
If our reneal system is good enough
We will be able to excret a good amount of sodium and extracellular fluid
However with hypertension, it won’t be so it’ll retain it and cause high blood pressure
How does RAAS from renal system effect blood pressure ?
It’s our body’s response to the change and in low BP and will try to retain sodium and fluids in order to try to increase it but without good sodium excretion, the body will overaccumilate in collection of sodium
How does prostaglandins from ther renal system effect our blood pressure?
Our body produces prostaglandins in order to try to lower it by working as a
Vasodilator
How does natriuretic peptides work to effect blood pressure?
They oppose ( anti diuretic hormone ) ADH and Aldosterone
Which pretty much these two help retain fluids and sodium but since they are being opposed
It helps us lower blood pressure & lower blood volume
What are the steps of how epinephrine and nonepinephrine factor into influence our blood pressure? (7)
Epinephrine and nonepnephrine are relaxed by the adrenal medulla
They both increase cardiac output and contractility
This activates B2 receptors in the skeletal muscle and causes Vasodilation
Then it activates A1 adrenergic receptors in the skin & kidneys and causes vasoconstriction
Which also angiotensin 2 stimulates aldosterone to be released from the adrenal cortex in order to promote Fluid retention
Also ADH comes from posterior partition to increase fluid volume retention
All of this causing our blood pressure to increase
What’s normal blood pressure
Elevated blood pressure
HTN stage 1
HTN stage 2
120/80
120-129/80
130-139/80-89
140+/90+
Primary/essential Hypertension
Elevated BP is due to what?
And what percentages of all cases?
Unknown cause
90-95% of all cases of hypertension
What are the many contributing causes of primary/essential hyper tension? (9)
EEEOOO anagram
Altered endothelial function
Diabetes
Excess alcohol
Increased SNS activity
Increase sodium intake
Overproduction of Sodium
Overweight
retaining hormones
Tobacco
Secondary HTN
Elevated blood pressure is what cause?
And it accounts to what percentage of cases ?
Specific ; sudden development cause
5-10%
What are some findings that related to secondary HTN ? (8)
Aortic problems
Cirrhosis
Drug related
Endocrine
Neurological
Pregnancy induced
Renal problems
Sleep apnea
What is the treatment of secondary HTN?
Removing or treating the underlying cause