Hypertension Flashcards

1
Q

What are causes of hypertension?

A
Obesity
Lack of physical activity
Too much sodium in diet
Older Age
Family history of hypertension
Chronic kidney disease
Too much alcohol consumption
Insufficient intake of potassium, magnesium, & calcium
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2
Q

Who determined the categories for HPTN?

A

JNC-7

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3
Q

What do HPTN drugs do?

A

Support lifestyle modifications

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4
Q

What drugs are prescribed for Stage 1 HPTN without compelling indications?

A

Thiazide-type diuretic for most.

May consider ACEI, ARB, beta-blocker, CCB, or combination

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5
Q

What drugs are prescribed for Stage 2 HPTN without compelling indications?

A

2 drug combo for most.

Usually a thiazide and ACE-I or beta-blocker, or CCB

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6
Q

What drugs are prescribed for hypertension without compelling indications?

A

Drugs for compelling indications.

Other antihypertensive drugs as needed.

  • Diuretics
  • ACE-I
  • ARB
  • beta-blockers
  • CCB
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7
Q

What HPTN drugs are preferred in pregnancy?

A

Methyldopa
Beta Blocker
Vasodilators

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8
Q

What HPTN drugs should be avoided in pregnancy?

A

ACE Inhibitors

Angiotension Receptor Blockers

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9
Q

What is a possible contraindication to prescribing diuretics?

A

Dyslipidemia

*Diabetes

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10
Q

What are compelling contraindications of diuretics?

A

Gout

Allergy to sulfa-based diuretics

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11
Q

What are possible contraindications to prescribing beta-blockers?

A

Asthma
COPD
Dyslipidemia
Severe Peripheral Vascular Disease

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12
Q

What are compelling contraindications of beta blockers?

A

Bronchospastic disease

Second or third-degree heart block

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13
Q

What are possible contraindications of calcium channel blockers?

A

None

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14
Q

What are compelling contraindications of calcium channel blockers?

A

Second or third-degree heart block

Heart failure

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15
Q

Where do you want to use caution with hypertensive medication combinations?

A

Elderly patients

Combinations mask if one agent would have been sufficient.

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16
Q

What are adverse drug reactions of reserpine?

A
Central nervous system sedation, depression, nightmares.
Extrapyramidal effects (e.g. tremor)
17
Q

What is the mechanism of action of reserpine?

A

Neurotransmitter reuptake blockade of norepinephrine, dopamine, serotonin.

BIG blood pressure decreases.

18
Q

What is the effect of reserpine?

A

Irreversible!

19
Q

What is reserpine used for?

A

Psychiatric disorders.

Used worldwide.

20
Q

What are the adverse drug reactions of guanethidine?

A

Hypotension- postural and post-exercise.

21
Q

What is the mechanism of action for guanethidine?

A

Norepinephrine release inhibition - gradual depletion of norepinephrine in nerve endings.

22
Q

True or false: guanethidine has few drug-drug interactions?

A

False! Many drug interactions.

Not marketed in the US