Hypersensitivity Pneumonitis Flashcards

0
Q

HP caused by thermophilic actinomycetes found in sugar cane

A

Bagassosis

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1
Q

Most common types (3) of hypersensitivity pneumonitis in the US

A

Farmer’s lung, bird fancier’s lung, and chemical worker’s lung

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2
Q

Antigen responsible for cheese washer’s lung

A

Penicillium casei

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3
Q

Antigen responsible for chemical worker’s lung

A

Isocyanates

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4
Q

Antigen responsible for detergent worker’s disease and familial HP

A

Bacillus subtilis

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5
Q

Two genera of thermophilic actinomycetes responsible for HP

A

Micropolyspora and Thermoactinomyces

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6
Q

Antigens (2) responsible for hot tub lung

A

Cladosporium spp. and Mycobacterium avium complex

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7
Q

Antigen responsible for Japanese-summer type HP

A

Trichosporon spp.

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8
Q

Antigens responsible for metalworking fluid lung

A

Mycobacterium spp. and Pseudomonas spp.

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9
Q

Antigen found in infested wheat flour responsible for miller’s lung

A

Sitophilus granarius

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10
Q

HP caused by Penicillium glabrum and Chrysonilia sitophila from cork dust

A

Suberosis

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11
Q

Antigen responsible for winegrower’s lung

A

Botrytis cinerea

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12
Q

Antiretroviral drug associated with HP

A

Efavirenz

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13
Q

Antituberculous medication associated with HP

A

Isoniazid

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14
Q

In HP, increase in these cells in lavage fluid has been associated with lung fibrosis

A

Polymorphonuclear leukocytes

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15
Q

Clinical manifestation of HP with the greatest predictive value for mortality

A

Pulmonary fibrosis

16
Q

This part of the lung is commonly spared in HP

17
Q

Procedure of choice for imaging in HP

A

High-resolution chest CT

18
Q

Triad of subacute HP on lung biopsy

A

Mononuclear bronchiolitis, interstitial infiltrates of lymphocytes and plasma cells, and single, nonnecrotizing, randomly scattered parenchymal granulomas without mural vascular involvement

19
Q

Transient fever and muscle aches, with or without dyspnea and cough; absent serum precipitins, normal chest x-ray; associated with heavy exposure to organic dusts

A

Organic dust toxic syndrome

20
Q

Fever, chills, cough and pulmonary infiltrates within a few hours of exposure to moldy silage; absent precipitins

A

Pulmonary mycotoxicosis

21
Q

Pattern of bronchiectasis in ABPA

22
Q

Main diagnostic criteria for ABPA (6)

A

(1) Bronchial asthma, (2) central bronchiectasis, (3) peripheral eosinophilia (more than 1000/uL), (4) immediate wheal-and-flare to A. fumigatus, (5) pulmonary infiltrates, (3) elevated serum IgE, (6) serum precipitins to A. fumigatus

(BCPIPES)

23
Q

Most common cause of ABPA

A

Aspergillus fumigatus

24
Tropical eosinophilia is usually caused by infection with these organisms
Filaria
25
Most common cause of eosinophilic pulmonary infiltrates in the US
Drug-induced eosinophilic pneumonias
26
Benign, acute eosinophilic pneumonia of unknown cause characterized by migrating pulmonary infiltrates and minimal clinical manifestations; may be secondary to drugs or parasites
Loeffler's syndrome
27
BAL fluid finding in acute eosinophilic pneumonia
Greater than 25% eosinophils
28
Normal eosinophil (%) in BAL fluid in nonsmokers
Less than 2%
29
Level of eosinophilia and duration in hypereosinophilic syndrome
More than 1500 eosinophils/uL for 6 months or longer
30
Heart valve commonly involved in hypereosinophilic syndrome
Tricuspid valve
31
Surgery associated with hypereosinophilic syndrome
Lung/bone marrow transplantation
32
Malignancy associated with hypereosinophilic syndrome
T cell lymphoma
33
Internationally, this is the most common form of HP
Bird breeder's lung
34
Most common cause of pediatric HP
Bird breeder's lung
35
Most common cause of pulmonary infiltrates with eosinophila worldwide
Parasitic infestation