Hypersensitivity Intro Flashcards
Define hypersensitivity
The antigen specific immune responses that are either inappropriate or excesssive + result in harm to host
Types of triggers (antigens)
- exogenous: non infectious substances, infectious microbes, drugs
- intrinsic: infectious microbes, self antigens (autoimmunity)
Types of hypersensitivity reactions
- Type I or immediate (Allergy)
- Type II or antiBody-dependent cytotoxicity
- Type III or immune Complexes mediated
- Type IV or cell mediated (Delayed)
What is the sensitisation phase?
- first encounter with antigen
- activation of APCs + memory effector cells
What does it mean is a person is ‘sensitised’?
A previously exposed individual to the antigen is said to be ‘sensitised’
What is the effector phase of hypersensitivity reactions?
Pathologic reaction upon re-exposure to the same antigen + activation of memory cells of adaptive immunity
Describe type II hypersensitivity
- antibody dependent cytotoxicity
- usually develops within 5-12hrs re encounter
- IgG + IgM involved
-
targets cell bound antigens:
-exogenous: blood group antigens, Rhesus D antigens
-endogenous: self antigens (autoimmune) - induces tissue/cell damage or physiological change
Outline Type II hypersensitivity associated with tissue/cell damage
- IgG + IgM antibodies raised against cell bound antigens
- complement activation: cell lysis, neutrophil recruitment, opsonisation
- antibody dependent cell cytotoxicity: natural killer cells
What immunoglobulins are related to hypersensitivity reactions
Type I - IgE
Type II + III - IgG + IgM
Clinical examples of Type II hypersensitivity assocaited with tissue/cell damage - complement activation
What is the antigen?
- haemolytic disease of newborn - Rhesus D
- transfusion reactions - ABO system
When does Type II hypersensitivity occur?
Within 5-12 hours re-encounter
Clinical examples of Type II hypersensitivity assocaited with tissue/cell damage - antibody-dependent cell cytoxicity
What is the antigen?
- autoimmune haemolytic anaemia - RBCs
- immune thrombocytopenic purpua - platelets
- goodpasture’s syndrome - collagen in glomerular basement memebrnae
Outline haemolytic transfusion reaction
- incorrect blood is given
- incompatibility of ABO antigens on RBCs
- donor RBC lysis induced induced by type II hypersensitivity reaction IgM
- causing shock, respiratory distress, kidney failure + death
Outline Type II hypersensitivity associated with physiological changes
immune response against receptor
(Type V)
- IgG reaction against cell bound antigens
- receptor stimation
- receptor blockade
- protein blockage
Clinical examples of Type II hypersensitivity assocaited with physiological changes
What is the antigen?
- receptor stimulation: Grave’s disease - TSH receptor
- receptor blockade: myasthenia gravis - acetylcholine receptor
- protein blockade: pernicious anaemia - intrinsic factor