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SCT2 Systems Immunity > Hypersensitivity Disorders > Flashcards

Hypersensitivity Disorders Flashcards

1
Q

Hypersensitivity disorders refer to excessive or inappropriate activation of the immune system to what 2 types of inflammatory, tissue damaging antigens??

A

EXOGENOUS
and
ENDOGENOUS (from within)

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2
Q

List the 4 basic categories (TYPES) of hypersensitivity responses?

A 
#1. IMMEDIATE HYPERSENSITIVITY
#2. ANTIBODY MEDIATED HYPERSENSITIVITY
#3. IMMUNE COMPLEX MEDIATED HYPERSENSITIVITY
#4. DELAYED OR CELL MEDIATED HYPERSENSITIVITY
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3
Q

Which antibody is ‘immediate hypersensitivity’ (type #1) mediated by?

A

IgE

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4
Q

What does endogenous mean?

A

FROM WITHIN

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5
Q

Type 1, immediate hypersensitivity, generally involves what?

A

ALLERGIES

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6
Q

Which antibody is ‘antibody mediated hypersensitivity’ (type #2) mediated by?

A

IgM or IgG

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7
Q

Type 2, antibody mediated hypersensitivity, generally involves what?

A

BLOOD

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8
Q

What is hemolysis?

A

BREAKING APART OF BLOOD CELLS

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9
Q

What are erythrocytes?

A

RED BLOOD CELLS

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10
Q

Which antibody is ‘immune complex mediated hypersensitivity’ (type #3) mediated by the formation of?
* 3 things

A
  1. ANTIGEN-IMMUNOGLOBIN COMPLEXES
  2. COMPLIMENT FIXATION
  3. LOCALIZED INFLAMMATION
    (Involves IgM and IgG)
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11
Q

Type 3, immune complex mediated hypersensitivity, generally involves what?

A

ANTIGEN and ANTIBODY PAIR, CAUSING DAMAGE

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12
Q

Which antibody is ‘delayed or cell mediated hypersensitivity’ (type #4) mediated by?

A

SPECIFICALLY SENSITIZED T - LYMPHOCYTES

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13
Q

Type 4, delayed or cell mediated hypersensitivity, generally involves what?

A

SKIN

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14
Q

Local: allergic rhinitis, asthma, urticaria (hives), angioedema, gastrointestinal food allergies
Systemic: anaphylaxis (life threatening) …
- are all examples of which type of hypersensitivity disorder?

A

TYPE #1. IMMEDIATE HYPERSENSITIVITY

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15
Q

Erythroblastosis fetalis, blood transfusion reactions, autoimmune hemolytic anemia, autoimmune thrombocytopenia…
- are all examples of which type of hypersensitivity disorder?

A

TYPE #2. ANTIBODY MEDIATED HYPERSENSITIVITY

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16
Q

Arthus reaction, serum sickness, glomerulonephritis, polyarteritis nodosa…
- are all examples of which type of hypersensitivity disorder?

A

TYPE #3. IMMUNE COMPLEX MEDIATED HYPERSENSITIVITY

17
Q

Contact dermatitis, graft rejection

- are both examples of which type of hypersensitivity disorder?

A

TYPE #4. DELAYED OR CELL MEDIATED HYPERSENSITIVITY

SCT2 Systems Immunity (11 decks)

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