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MOD 2 > Hypersensitivity Diseases > Flashcards

Hypersensitivity Diseases Flashcards

1
Q

Sjogren syndrome auto-ab

A

anti Ro/SS-A

anti La/SS-B

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2
Q

CREST auto-ab

A

anticentromeric antibody

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3
Q

Pernicious anemia = what hypersensitivity

A

Type 2

Neutralization

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4
Q

SLE auto-ab

A

anti-ds DNA

anti-Sm

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5
Q

Discoid lupus auto-ab

A

(-) Anti-DS DNA

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6
Q

Goodpasture syndrome Auto-Ab

A

anti-basement membrane, anti-tupe 4 collagen

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7
Q

NOD2

A

Chron’s

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8
Q

Autoimmune hemolytic anemia

Autoimmune thrombocytopenic purpura

A

Type 2

Opsonization + Phagocytosis

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9
Q

Ankylosing spondylitis (HLA alleles B 2705 + B 2702) hugely predisposes you to?

A

Autoimmune disease

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10
Q

PTPN22

A

Rheumatoid arthritis, type 1 diabetes

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11
Q

Autoimmune diseases on the rise because?

A

Less IL-2 –> need to maintain T regs

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12
Q

What are the 4 diseases of type 2 hypersensitivity from antibody-mediated cellular dysfunction?

A

Myasthemia gravis

Graves

Insulin-resistant diabetes

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13
Q

What are the 3 types of type 2 hypersensitivity reactions?

A
  1. Opsonization + phagocytosis
  2. Inflammation (from complement)
  3. Antibody-mediated cellular dysfunction
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14
Q

Reactions where antibodies directly react w/ antigens present on the cell surface = what hypersensitivity

A

Type 2

smooth, linear

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15
Q

Hypersensitivity reaction mediated by T cells:

A

Type 4

Granuloma

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16
Q

Tuberculosis

A

Type 4

Delayed Type Hypersensitivity

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17
Q

Eosinophilic esophagitis

A

Type 1

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18
Q

“Antigen-antibody complexes form and deposit, causing damage”

how doe sit look?

A

Type 3

Grainy, granular

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19
Q

Systemic sclerosis (scleraderma) auto-ab

A

anti-DNA topoisomerase

20
Q

Poststreptococcal glomerulonephritis =

A

Type 3

21
Q

What are Type 1 Hypersensitivity Reactions?

A

Seasonal Allergies

Food allergies

Asthma

Severe Allergic Reactions (hives, angioedema, anaphylaxis)

22
Q

Mixed connective tissue disease auto-ab

A

anti-U1-ribonucleoprotein

23
Q

Serum sickness + Arthus reaction =

A

Type 3

24
Q

Opsonization + phagocytosis lead to –> which Sx?

A

Anemia

Thrombocytopenia

25
Q

IgG4 =

A

Mickulicz

Autoimmune pancreatitis

26
Q

What are the 6 types of type 4 hypersensitivity reactions?

A

In Rural Montana People Tip Cows

Inflammatory Bowel Disease

Rheumatoid Arthritis

Mltiple Sclerosis

Psoriasis

Type 1 Diabetes

Contact Sensitivity (from posion ivy/nickel)

27
Q

What is eosinophilic esophagitis?

A

Can’t swallow effectivitly/hurts to swallow –> weight loss

28
Q

Lupus Erythematosus: associated w/ persistent antibody resposnses to autoantigens

A

Type 3

29
Q

Inflammation + damaged tissue lead to which hypersensitivity reactions?

A

Type 2

  • Vasculitis by ANCA, Goodpasture syndrome, Acute rheumatic fever
30
Q

drug-induced SLE auto-ab

A

anti-histone Ab

31
Q

X-linked agammglobunemia

A

BTK (bruton tyrosine kinase)

Inability of pre-B cells to mature

32
Q

Hyper - IgM

A

CD40L mutation on T cells

Interfere w/ T cells helping B cells to class-switch

–> result is high levels of default IgM

33
Q

X-linked SCID (more common)

AR SCID

A

cytokine y chain

adenosine deaminase

34
Q

CVID

A

Multiple disoders resulting in hypogammaglobulinemia

Diagnosis of exclusion

Chronic diarrhea, anemia, thrombocytopenia, recurrent sinus + pulmonary infections (lack of IgA)

35
Q

IgA deficiency

A

IgA deficiency can cause recurrent sinus infections / UTIs.

The main presentation however is an anaphylactic reaction to blood transfusion. In response, we can either wash out the IgA, or give a transfusion from IgA deficient donors.

36
Q

Wiskcott-Aldrich 3 things:

A

Eczema

Thrombocytopenia

Recurrent infections

37
Q

Ataxia Telegiectasia

A

Ataxia telangiectasia is a rare genetic disease that presents first with neurodegenerative sx, but then progresses to vascular malformation (telangiectasias towards the iris), and sx of IgA and IgG deficiency. These include respiratory infections, and a dramatically increased risk of lymphoma.

AR - ATM mutation

38
Q

Skin MCC

A

Basal cell carcinoma #1

squamous cell carcinoma

malignant melanoma

39
Q

brain MCC

A

glial neoplasm

40
Q

What most common cancers are squamous cell carcinoma?

A

oral cavity, head, neck

lung (4th)

cervix

esophagus

skin (2nd)

41
Q

Adenocarcinoma

A

lung

pancreas

large bowel (colon)

kidney

prostate

Endometrium

42
Q

breast MCC

A

invasixe ductal carcinoma

43
Q

bladder MCC + pelvis of kidney

A

transitional epithelium

44
Q

Liver MCC

A

hepatocellular carcinoma

45
Q

Testes

A

germ cell origin

46
Q

Most common cancers of adults in western society

A

Skin

Oral cavity, head, neck

Lung

Large bowel (colon)

Prostate

Breast

Cervix

47
Q

Lung MCC

A

adenocarcinoma #1

small/large cell undifferentiated carcinoma

squamous cell carcinoma

MOD 2 (9 decks)

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