Hypersensitivity and Allergy

Question 1

Type I

Answer 1

IgA mediated (allergy)

Question 2

Type II

Answer 2

cytotoxic/antibody dependent (myasthenia gravis)

Question 3

Type III

Answer 3

antibody-antigen dependent (immune complex) SLE

Question 4

Type IV

Answer 4

DTH (T cell mediated) RA

Question 5

Why has tolerance failed (5)

Answer 5

1. failure of privileged sites
2. incomplete clonal deletion
3. failures of apoptotic mechanisms
4. failure to regulate (Ipex gene - Treg cells) (FOXp3)
5. T-cell bypass concept

Question 6

Therapeutic control of autoimmunity (4)

Answer 6

1. NSAIDS
2. corticosteroids (immuno-suppressants)
3. reconstituting function (insulin)
4. Biologicals (Anti-TNFalpha)