Hypersensitivity Flashcards
What is Type I
Anaphylactic
What is type II
Cell bound
What is type III
Immune complex
What is type IV
Delayed hypersensitivity
Type I mechanism
Antigen reacts with IgE bound to mast cells
Type I examples (2)
Anaphylaxis
Atopy (asthma, eczema, hay fever)
Anaphylaxis
I
Atopy
I
Type II mechanism
IgG or IgM binds to antigen on cell surface
Type II examples (7)
Autoimmune haemolytic anaemia ITP Goodpastures syndrome Pernicious anaemia Acute haemolytic transfusion reactions Rheumatic fever Pemphigus vulgaris/bullous pemphigoid
Autoimmune haemolytic anaemia
II
ITP
II
Goodpastures syndrome
II
Pernicious anaemia
II
Acute haemolytic transfusion reactions
II
Rheumatic fever
II
Pemphigus vulgaris/bullous pemphigoid
II
Type III mechanism
Free antigen and antibody combine
Type III examples (4)
Serum sickness
SLE
Post streptococcal glomerulonephritis
Extrinsic allergic alveolitis
Serum sickness
III
SLE
III
Post streptococcal glomerulonephritis
III
Extrinsic allergic alveolitis
III
Type IV mechanism
T cell mediated
Type IV examples (7)
TB Graft vs host disease Allergic contact dermatitis Scabies Extrinsic allergic alveolitis MS Guillian Barre
TB
IV
Graft vs host disease
IV
Allergic contact dermatitis
IV
Scabies
IV
Extrinsic allergic alveolitis
IV
MS
IV
Guillian Barre
IV
Type V mechanism
Antibodies that recognise and bind to the cell surface receptors
Type V examples (2)
Graves’ disease
Myasthenia gravis
Graves’ disease
V
Myasthenia gravis
V
