hyperlipidemia lab Flashcards
vytorin
simvastatin with ezetimibe
juvisync
simvastatin with sitagliptin
fluvastatin brand
lescol
fluvastatin dosing
low: 20-40 mg/day
moderate: 80 mg/day
pitavastatin brand
livalo
pitavastatin dosing
low: 1 mg/day
moderate: 2-4 mg/day
lovastatin brand
mevacor
altoprev
lovastatin dosing
low: 20 mg/day
moderate: 40 mg/day
pravastatin brand
pravachol
pravastatin dosing
low: 10-20 mg/day
moderate: 40-80 mg/day
simvastatin brand
zocor
simvastatin dosing
low: 10 mg/day
moderate: 20-40 mg/day
atorvastatin brand
lipitor
atorvastatin dosing
moderate: 10-20 mg/day
high: 40-80 mg/day
rosuvastatin brand
crestor
rosuvastatin dosing
moderate: 5-10 mg/day
high: 20-40 mg/day
statin SE
- Myopathy
- Rhabdomyolysis
- Myositis
- Muscle pain
- Liver enzyme abnormalities
- HA
- Dyspepsia
- Abdominal pain
- Nausea
- Upper respiratory infection
statin monitoring
- FLP: Baseline, 4-12 weeks after starting, Every 3-12 months
- CK: Baseline, If muscle symptoms
- LFTs: Baseline, Repeat if indicated
- Skeletal Muscle SEs
ezetimibe brand
zetia
ezetimibe dosing
10 mg/day
ezetimibe SE
- Arthralgia
- Upper respiratory tract infection
- Diarrhea
ezetimibe monitoring
- FLP baseline
- LFTs
alirocumab brand
praluent
alirocumab dosing
- 75 mcg SQ q2weeks
- 150 mcg SQ q2weeks post 4-8 weeks
evolocumab brand
repatha
evolocumab dosing
120 mcg SQ q2 weeks
420 mcg SQ monthly
PCKS9 inhibitor SE
- GI side effects
- ↑ LFT
- Injection site reaction
- Myalgia
- Influenza
PCKS9 inhibtor monitoring
- LDL-C within 4-8 weeks of starting or changing dose
- Hypersensitivity
omega-30acid ethyl esters brand
lovaza
omega-30acid ethyl esters brand dosing
- 4 g/day
- 2 g BID
omega-30acid ethyl esters brand SE
- GI – diarrhea
- Dysgeusia
- Dyspepsia
- Eructation
- Nausea
omega-30acid ethyl esters brand monitoring
- TG and LDL at baseline and periodically
- ALT periodically
- GI disturbances, skin changes, bleeding
cholestyramine brand
Questran
Prevalite
cholestyramine dosing
4g (1 packet or scoop) once or BID
-MAX: 24 g/day
colesevelam brand
welchol
colesevelam dosing
- 75 g QD
1. 875 g BID
colestipol brand
colestid
colestipol dosing
- start: 5g once or BID
- increase by 5g at 1-2 month intervals
- go up to 30g/day in divided doses
colsevelam, cholestyramine and colestipol SE
- increased TG
- Constipation
- Bloating
- Nausea
- Flatulence
- deceased absorption of fat-soluble vitamins
- Hypernatremia
- Hyperchloremia
- GI Obstruction
colsevelam, cholestyramine and colestipol monitoring
- FLP: Baseline, 3 months after, q6—12 months after
- Should not use if TG >300 mg/dL
niacin brand
niacor
niaspan
slo-niacin
niacin dosing
- start: 500 mg QHS x4 weeks
- go to 1g QHS x4 weeks
- MAX: 2g/day
- usual: 1-2 g/day QHS
niacin SE
- Prostaglandin mediated flushing and itching
- Skin rash
- Upset stomach
- Low blood pressure when standing
niacin monitoring
- LFT baseline
- FBH or A1C
- Uric acid
- Monitor during titration and every 6 months after
gemfibrozil brand
lopid
gemfibrozil dosing
600 mg BID 30 min AC
fenofibrate brand
tricor
fenofibric acid brand
trilipix
fibricor
tricor dosing
48-145 mg/day
MAX: 145 mg/day
trilipix dosing
45-135 mg/day
MAX: 135 mg/day
fibricor dosing
35-105 mg/day
MAX: 105 mg/day
fibrate SE
- GI disturbances
- Rash
- Myalgia
- Dizziness
- Anemia, leukopenia, thrombocytopenia
- Renal insufficiency
gemfibrozil monitoring
- Serum cholesterol
- LFTs
- CBC – first year
fenofibrate and fenofibric acid monitoring
- Periodic blood cell count – first year
- FLP every 6-8 weeks until goal then every 4-6 months
- LFTs
- Renal function: Baseline, 3 months after, Every 6 months
- Adjust following lipid determinations at 4-8 week intervals
- Consider reducing if lipids significantly lower than target
