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module 2a > hyperlipidemia lab > Flashcards

hyperlipidemia lab Flashcards

1
Q

vytorin

A

simvastatin with ezetimibe

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2
Q

juvisync

A

simvastatin with sitagliptin

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3
Q

fluvastatin brand

A

lescol

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4
Q

fluvastatin dosing

A

low: 20-40 mg/day
moderate: 80 mg/day

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5
Q

pitavastatin brand

A

livalo

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6
Q

pitavastatin dosing

A

low: 1 mg/day
moderate: 2-4 mg/day

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7
Q

lovastatin brand

A

mevacor

altoprev

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8
Q

lovastatin dosing

A

low: 20 mg/day
moderate: 40 mg/day

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9
Q

pravastatin brand

A

pravachol

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10
Q

pravastatin dosing

A

low: 10-20 mg/day
moderate: 40-80 mg/day

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11
Q

simvastatin brand

A

zocor

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12
Q

simvastatin dosing

A

low: 10 mg/day
moderate: 20-40 mg/day

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13
Q

atorvastatin brand

A

lipitor

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14
Q

atorvastatin dosing

A

moderate: 10-20 mg/day
high: 40-80 mg/day

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15
Q

rosuvastatin brand

A

crestor

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16
Q

rosuvastatin dosing

A

moderate: 5-10 mg/day
high: 20-40 mg/day

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17
Q

statin SE

A
  • Myopathy
  • Rhabdomyolysis
  • Myositis
  • Muscle pain
  • Liver enzyme abnormalities
  • HA
  • Dyspepsia
  • Abdominal pain
  • Nausea
  • Upper respiratory infection
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18
Q

statin monitoring

A
  • FLP: Baseline, 4-12 weeks after starting, Every 3-12 months
  • CK: Baseline, If muscle symptoms
  • LFTs: Baseline, Repeat if indicated
  • Skeletal Muscle SEs
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19
Q

ezetimibe brand

A

zetia

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20
Q

ezetimibe dosing

A

10 mg/day

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21
Q

ezetimibe SE

A
  • Arthralgia
  • Upper respiratory tract infection
  • Diarrhea
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22
Q

ezetimibe monitoring

A
  • FLP baseline

- LFTs

23
Q

alirocumab brand

A

praluent

24
Q

alirocumab dosing

A
  • 75 mcg SQ q2weeks

- 150 mcg SQ q2weeks post 4-8 weeks

25
Q

evolocumab brand

A

repatha

26
Q

evolocumab dosing

A

120 mcg SQ q2 weeks

420 mcg SQ monthly

27
Q

PCKS9 inhibitor SE

A
  • GI side effects
  • ↑ LFT
  • Injection site reaction
  • Myalgia
  • Influenza
28
Q

PCKS9 inhibtor monitoring

A
  • LDL-C within 4-8 weeks of starting or changing dose

- Hypersensitivity

29
Q

omega-30acid ethyl esters brand

A

lovaza

30
Q

omega-30acid ethyl esters brand dosing

A
  • 4 g/day

- 2 g BID

31
Q

omega-30acid ethyl esters brand SE

A
  • GI – diarrhea
  • Dysgeusia
  • Dyspepsia
  • Eructation
  • Nausea
32
Q

omega-30acid ethyl esters brand monitoring

A
  • TG and LDL at baseline and periodically
  • ALT periodically
  • GI disturbances, skin changes, bleeding
33
Q

cholestyramine brand

A

Questran

Prevalite

34
Q

cholestyramine dosing

A

4g (1 packet or scoop) once or BID

-MAX: 24 g/day

35
Q

colesevelam brand

A

welchol

36
Q

colesevelam dosing

A
  1. 75 g QD

1. 875 g BID

37
Q

colestipol brand

A

colestid

38
Q

colestipol dosing

A
  • start: 5g once or BID
  • increase by 5g at 1-2 month intervals
  • go up to 30g/day in divided doses
39
Q

colsevelam, cholestyramine and colestipol SE

A
  • increased TG
  • Constipation
  • Bloating
  • Nausea
  • Flatulence
  • deceased absorption of fat-soluble vitamins
  • Hypernatremia
  • Hyperchloremia
  • GI Obstruction
40
Q

colsevelam, cholestyramine and colestipol monitoring

A
  • FLP: Baseline, 3 months after, q6—12 months after

- Should not use if TG >300 mg/dL

41
Q

niacin brand

A

niacor
niaspan
slo-niacin

42
Q

niacin dosing

A
  • start: 500 mg QHS x4 weeks
  • go to 1g QHS x4 weeks
  • MAX: 2g/day
  • usual: 1-2 g/day QHS
43
Q

niacin SE

A
  • Prostaglandin mediated flushing and itching
  • Skin rash
  • Upset stomach
  • Low blood pressure when standing
44
Q

niacin monitoring

A
  • LFT baseline
  • FBH or A1C
  • Uric acid
  • Monitor during titration and every 6 months after
45
Q

gemfibrozil brand

A

lopid

46
Q

gemfibrozil dosing

A

600 mg BID 30 min AC

47
Q

fenofibrate brand

A

tricor

48
Q

fenofibric acid brand

A

trilipix

fibricor

49
Q

tricor dosing

A

48-145 mg/day

MAX: 145 mg/day

50
Q

trilipix dosing

A

45-135 mg/day

MAX: 135 mg/day

51
Q

fibricor dosing

A

35-105 mg/day

MAX: 105 mg/day

52
Q

fibrate SE

A
  • GI disturbances
  • Rash
  • Myalgia
  • Dizziness
  • Anemia, leukopenia, thrombocytopenia
  • Renal insufficiency
53
Q

gemfibrozil monitoring

A
  • Serum cholesterol
  • LFTs
  • CBC – first year
54
Q

fenofibrate and fenofibric acid monitoring

A
  • Periodic blood cell count – first year
  • FLP every 6-8 weeks until goal then every 4-6 months
  • LFTs
  • Renal function: Baseline, 3 months after, Every 6 months
  • Adjust following lipid determinations at 4-8 week intervals
  • Consider reducing if lipids significantly lower than target

module 2a (13 decks)

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