Hyperlipidemia Flashcards
3 factors increasing lipids?
nutrition
genetics
metabolic dx
primary hypercholesterimia is associated with a what predispoition?
genrtic
2ndary hypercholesterimia is associated with what?
health problems and behaviors
a lesion isnt considered critical until it reaches what % of occulsion?
90% of blood vessel
stable angina, acute coronary syndromes, PAD, CVA, acute aterial occulsion, aneurysm formation due to weakening of vessel wall are all comps of what dx?
atherosclerosis
plaques found in atherosclerosis are rich in what?
cholesterol
high LDL=?
High HDL=?
atherosclerotic dx
lower risk of CHD
majority of serum cholesterol consists of LDL we use total cholesterol as a what?
target risk factor
men and women are not effected the same way
men we are more concerned with what?
women?
LDL-men are more dependent on having low LDL
HDL-women are more dependent on having high HDL
genetic disorder which creates absent or defective LDL cell surface receptors leading to unregulated LDL synthesis?
familial hypercholesterolemia
in familial hypercholesterolemia what will LDLs be in children and adults?
> 155
>190
homo and heterozygous trait?
homo-liver transplant
hetero-CHD in 30s or 40s
eruptive xanthoma on ass
extremely high truglycerides >1000mg
tendinous xanthomas on achilles, patella, back of hand
high LDL
lipidemia retinalis or milky white vasculature
triglycerides >2000mgs
high intensity:
atorvastatin
rousuvastatin
low intensity:
pravstatin
louvastatin
baseline fasting lipid panel/ALT/CPK
when starting statins
which is montiored throughout tx with statins?
fasting lipid panel
Check a CPK, creatinine and myoglobinuria
Consider other pathologies
hypothyroidism, AKI, liver failure, rheumatic disorders, primary muscle disease
concern for rhabdomyolysis
muscle pain, weakness and dark urine, makes us suspicious of what?
rhabdomylosis
adb obesity men >40
women >35
tryglycerides >150
HDL: MEN <40
WOMEN <50
BP: >130/80
fasting glucose: >110mg
all of this is the criteria for what?
metabolic syndrome, you need to have 3 of the conditions to have an increased risk of CHD, CHF, DM
tx of metabolic syndrome?
tx underlying causes (weight, HTN, ASA for CHD, tx high TG or low HDL)
hypertruglyceridemia: tx when it is above what?
1000mg
