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eosinophilic dermatoses > hypereosinophilic syndrome > Flashcards

hypereosinophilic syndrome Flashcards

1
Q

what is the criteria for HES hypereosinophilic syndrome?

A

eosinophilia (>1500 for > 6 months); signs of end organ involvement; AND no e/o infx, allergies, or other underlying causes

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2
Q

what is the # 1 cause of death

A

CHF

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3
Q

what are the 2 major subtypes ?

A

myeloproliferative HES and lymphocytic HES

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4
Q

myeloproliferative HES

A

FIP1L1-PDGFRA fusion gene, endomyocardial fibrosis/cardiomyopathy, may have increased serum tryptase and vitamin b12, hepatosplenomegaly and constitutional sx; Tx: imatinib, prednisone

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5
Q

lymphocytic HES

A

clonal T cell proliferation w/ increased IL-5, generally benign course compared to myeloproliferative HES, increased risk of T cell lymphoma; Tx: prednisone

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eosinophilic dermatoses (5 decks)

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