hypercoagulable states Flashcards
1
Q
What is factor V leiden?
A
Autosomal dominant mutation of factor V that is resistant to breakdown by protein C
2
Q
What is the presentation of Factor V?
A
Increased DVT & PE
Hx of multiple miscarriage
3
Q
how is Factor V leiden diagnosed?
A
activated protein C resisitance assay
PT/PTT will be normal
4
Q
How is factor leiden treated?
A
Anticoagulation
5
Q
What is the role of protein C?
A
Inhibits coagulation by inhibiting factor V and VIII.
It is vitamin K dependent that is made by the liver
6
Q
how is protein C deficiencies diagnosed?
A
Protein C or S functional assay
7
Q
A
