Anemia

Question 1

What are the most common cause of iron deficiency

Answer 1

Chronic blood loss: Menstruation, occult GI bleed (consider colon cancer in new onset anemia in older patients)

Question 2

What diagnostic features of iron defcnieny found on CBC?

Answer 2

MCV <80%:microcytic hypochromic RBC

Question 3

Iron studies suggesting iron deficiency will show?

Answer 3

1) Decreased ferritin <30 *****
2) low serum iron
3) Increased TIBC (transferrin)
4) Decreased Transferrin saturation

Question 4

Which anemia type is known to have increased RDW (red cell distribution?

Answer 4

Iron deficiiency: RBC are produced despite decrease iron. over time the RBC size decreases resulting in a variation of RBC size.

Question 5

Tx for iron deficiency?

Answer 5

Ferrous Sulfate 325 mg with OJ

Question 6

Alpha-thalassemia causes a mild anemia if only _____alpha-globin genes are deleted.

Answer 6

Alpha-thalassemia causes a mild anemia if only two alpha-globin genes are deleted.

Question 7

There are normally ____ alpha-globin genes found on a single copy of chromosome 16

Answer 7

2

Question 8

_______ is a manifestation of alpha-thalassemia when four alpha-globin genes are deleted.

Answer 8

Hydrops fetalis is a manifestation of alpha-thalassemia when four alpha-globin genes are deleted, thereby resulting in the formation of Hb Barts (γ4) which is incompatible with life.

Question 9

_________________is a manifestation of alpha-thalassemia when three alpha-globin genes are deleted, thereby resulting in very little alpha-globin formation and excessive beta-globin formation.

Answer 9

HbH disease: HbH (β4).

Question 10

_________is a genetic cause of microcytic anemia that presents due to deletions of the alpha-globin genes.

Answer 10

Alpha-thalassemia

Question 11

Alpha-thalassemia is asymptomatic if there is only alpha-globin gene deletion