Hyperaldosteronism and Conn's

Question 1

Hyperaldosteronism may be primary or secondary in origin and are classically associated with […] […] […] (which is often […] […] to multiple agents) and low […] […]

Answer 1

Hyperaldosteronism may be primary or secondary in origin and are classically associated with high blood pressure (which is often treatment resistant to multiple agents) and low serum potassium.

Question 2

Causes

[…] […] (Conn’s Syndrome)
Bilateral […]
Familial […]
Adrenal […]

Answer 2

Adrenal adenoma (Conn’s Syndrome)
Bilateral adrenal hyperplasia
Familial hyperaldosteronism
Adrenal carcinoma

Question 3

Features

[…]
[…]
Metabolic […]

Answer 3

Features

Hypertension
Hypokalaemia
Metabolic alkalosis

Question 4

Mc cause

Answer 4

bilateral idiopathic adrenal hyperplasia is the most common cause.

Question 5

1st line investigation

Answer 5

aldosterone/renin ratio

Question 6

Differentiate between bilateral adrenal hyperplasia and adrenal adenoma

Answer 6

adrenal venous sampling (AVS)

Question 7

Mx.
1. Adrenal adenoma
2. Bilateral adrenal hyperplasia

Answer 7

1. Resection
2. Aldosterone antagonists (K+ sparing diuretics) e.g. spironolactone