Delayed puberty Flashcards
no pubertal development by the age of […] in boys and […] in girls.
no pubertal development by the age of 15 in boys and 14 in girls.
Most common cause
constitutional delay of growth and puberty, in which children are ‘late bloomers’ and enter normal puberty later than their peers. They will eventually reach full normal height and development.
Dx of constitutional delay
hand-wrist X-ray –> confirm bone age, –> delayed in constitutional bone delay (epiphyseal plates are late to fuse)
Low gonadotrophin
Low gonadotrophin secretion induces pituitary disorders ([…], […] syndrome, panhypopituitarism or isolated […] deficiency), […], or systemic disease (e.g. […] […] or Crohn’s).
Low gonadotrophin secretion induces pituitary disorders (craniopharyngiomas, Kallmann syndrome, panhypopituitarism or isolated gonadotrophin deficiency), hypothyroidism, or systemic disease (e.g. cystic fibrosis or Crohn’s).
High gonadotrophin secretion causes include […] disorders ([…] XO, […] XXY), […] […] […] , or acquired […] (e.g. after chemotherapy)
High gonadotrophin secretion causes include chromosomal disorders (Turner’s XO, Klinefelter’s XXY), congenital adrenal hyperplasia, or acquired hypogonadism (e.g. after chemotherapy)