Hyper IgE syndrome

Question 1

Signs in hyper IgE

Answer 1

atopic dermatitis, recurrent cutaneous infections, and sinopulmonary infections, retention of primary teeth, coarse facial features

Question 2

Mutation on autosomal dominant for of Hyper IgE

Answer 2

STAT3 leading to impaired Th17 development

Question 3

Treatment of Hyper IgE

Answer 3

Prophylactic anti-staph antibx like Bactrim