Hydroa vacciniforme

Question 1

Onset.

when is the bimodal onset?

Answer 1

childhood.
1-7 and 12-16.
spont remission before age 20.

Question 2

manif

Answer 2

within 6 hrs of exposure, stinging beginsz at 24 hours or sooner; erythema and edema ff by 2-4 mm vesicles.
next few days, rupture necrotic, heal w small pox like scar.

Question 3

histo

Answer 3

Early lesions- intraepidermal vesiculatio ln and dermal edema that evilve into a subepidermal blister. necrotic lesions show reticular degeneration of keratinocytes. dermal vessels may be thrombosed. stimulating vasculitis.

Question 4

tx

Answer 4

Avoid sunlight.
sunblock
prophylactic nb uvb in spring
chloroquien and sys steroid.