hw 4 study set Flashcards
rate of drug dissolution is ___ proportional to particle size?
inversely
what can pH deependant drug release be achieved by?
enteric coating (shellac)
what improves drug release?
reduction in size or unstirred boundary layer
what plays major role in killing infected cells of antibodies?
glycosltion pattern
what is solid phase peptide syntheis?
peptide assembling on resin
deprotection and cleavage
column purification
lyphoilization
ion exchange
lypholization
packing and labelling
(depreotection, coupling, cleavage)
are antifboy based therapeutics produced from E coli?
no, peptide products are like hGH
PEGylation increases half-life while albumin-conjugation decreases half-life of a
protein therapeutic
false, both increase HL
sustained release and immediate release tablets can both be split in half without
affecting their in vivo performance
false, can only split IR and SR can be harmful
If we know the buffer-less rate constant of degradation of a peptide drug at multiple
higher temperatures?
we can calculate its shelf life at its storage temperature in a
refrigerator
Monoclonal antibodies are composed of?
two polypeptide chains bonded through
cysteine amino acids by disulfide bonds
Hydrolysis and deamidation of proteins, both usually proceed ?
through succinimide
intermediates
Ethyl cellulose can be used as a polymer when you want drug release from a matrix
by swelling?
no it is a non-swelling, hydrophobic polymer that relies primarily on the diffusion of the drug through the polymer matrix
Semaglutide by itself has?
low solubility and high permeability
A contraceptive drug formulated as a 200 mg PLGA-based intramuscular implant
will be able to release drug over a longer period of time as compared to the same drug
formulated as a 200 mg olive oil in water emulsion-based intramuscular depot.
true
what does effect of ionic strength on reaction rate k depend on?
the reaction rate constant depends on the nature of the reactants (charged vs neutral), the reaction mechanism, and the solvent.
