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Question 1

What are examples of oral dosageforms?

Answer 1

Tablets, capsules, orally dissolving tablets, sublingual tablets, solutions, suspensions, elixirs

Question 2

What is a diluent?
What are examples?

Answer 2

Increases the bulk of the tablet for ease of manufacturing, handling and swallowing

Microcrystalline cellulose, lactose anhydrous, starch, dextrose

Question 3

What are binders?

Answer 3

Impart cohesiveness to formulation

Bind power particles into granules during granulation

Bind granules into tablet during compression

Ex: starch, gelatin

Question 4

What are disintegrants?

Answer 4

Promotes tablet disintegration—> rapid uptake of water, swelling, increase in tablet porosity

Ex: starch, cellulose, crosspovidone

Question 5

What are lubricants?
Why does content and blending time need to be controlled?
What are examples?

Answer 5

Aid in tablet ejection

Reduces friction between die and tablet

To avoid coating of drug powder with waxes, increase of dissolution time & decrease bioavailability

Magnesium stearate, talc, stearic acid

Question 6

What are glidants?

Answer 6

Improve the flow of powders

Promotes uniformity of dosage form weight

Can affect dissolution & bioavailability (talc, colloidal silicon dioxide)