Huntington's Disease Flashcards
1
Q
Molecular Basis for huntington’s
A
CAG repeats on chromosome 4 within the huntingtin gene
Auto dominant
2
Q
Dystonia
A
Sustained muscle contractions that cause twisting or repetitive movements
3
Q
Tardive dyskinesia
A
Caused by continued use of dopamine antagonists such as typical antipsychotics
4
Q
Manifestations of huntingtons
A
Motor, cognitive, behavioral problems
- Chorea
- Problems with balance, dexterity, coordination
- Swallowing problems appear late
5
Q
Wetphal variant Huntington’s
A
Develops in childhood, early onset huntingtons
6
Q
Drugs used to treat chorea
A
Haloperidol….high potency neuroleptic
