Dementia and Dystonia

Question 1

Cortical dementia manifests as

Answer 1

Involvement of cognitive function while basic neurologic function remains intact. Language is aphasic though speech is intact, mental status is abnormal, Motor system is intact

Question 2

Subcortical dementia

Answer 2

Motor system affected, speech is abnormal,

Question 3

Posterior Cortical dementia prototype

Answer 3

alzheimers

Question 4

Characteristic histological changes of alzheimers

Answer 4

Neurofibrillary tangles and amyloid plaques

Question 5

Classic triad of gait instability, dementia, urinary or bowel incontinence

Answer 5

Normal pressure hydrocephalus…disturbances to CSF reabsorption

Question 6

Alzheimers tx regimen

Answer 6

Donepezil, Rivastigmine, Galantamine

Question 7

Donepezil and Rivastigmine are

Answer 7

cholinesterase inhibitors…inc acetylcholine

Question 8

Dystonia definition

Answer 8

Sustained muscle contractions that cause twisting repetitive movements and abnormal posture

Question 9

Myoclonus

Answer 9

Sudden jerking movement

Question 10

Opisthotonos

Answer 10

Great rigid spasm of the body with the back fully arched and the heels and head bent back.

Question 11

Most common genetic cause of generalized dystonia

Answer 11

GAG deletion in exon 5 of DYT1

Question 12

PET scans look at?

Answer 12

Glucose metabolism

Question 13

Dystonia most likely results from

Answer 13

Abnormal pattern of activity in the Basal Ganglia such as internal segment of globus pallidus and substantianigra pars reticularis

Question 14

The drug most likely to help relieve dystonic symptoms in a patient with DYT-1 Dystonia (Early Onset Generalized Dystonia)

Answer 14

Trihexyphenidyl