Hungingtons Chorea Flashcards
1
Q
What causes it?
A
Trinucleotide repeat disorder, Repeated expansion of CAG
2
Q
What is unique about the genetic aspect of this disease?
A
Each generation, the disease will show earlier and be more intense in symptoms.
3
Q
Early Signs?
A
Personality Changes Depression Apathy Clumsiness Dysarthria/phagia Abnormal eye movements
4
Q
Late Signs?
A
Chorea
Rigidity
Dementia
5
Q
Neurotransmitter effects?
A
Decreased GABA and Ach
Increased Dopamine
6
Q
Mx Option?
A
Tetrabenazine