Hungingtons Chorea Flashcards

1
Q

What causes it?

A

Trinucleotide repeat disorder, Repeated expansion of CAG

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2
Q

What is unique about the genetic aspect of this disease?

A

Each generation, the disease will show earlier and be more intense in symptoms.

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3
Q

Early Signs?

A
Personality Changes
Depression
Apathy
Clumsiness
Dysarthria/phagia
Abnormal eye movements
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4
Q

Late Signs?

A

Chorea
Rigidity
Dementia

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5
Q

Neurotransmitter effects?

A

Decreased GABA and Ach

Increased Dopamine

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6
Q

Mx Option?

A

Tetrabenazine

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