Creudzfelt Jacobs Disease Flashcards
1
Q
What is it?
A
Neurodegeneration causing cell death (spongiform changes in cortex) and astrocytosis
2
Q
Symptoms
A
Onset at 65
Rapidly progressive dementia and myoclonus
3
Q
Best initial ix?
A
EEG: pseudoperiodic biphasic, high amplitude, sharp wave acitivty
4
Q
CSF analysis?
A
Elevated 14-3-3 protein
5
Q
New variant CJD?
A
Younger patients
anxiety, withdrawn and dysphonia
6
Q
MRI findings?
A
Hyperintense signals in basal ganglia and thalmus
