Human Leukocyte Antigens Flashcards
1
Q
- True or false? The HLA complex is the most polymorphic genetic system known to date.
A
True
2
Q
- What is the most important biologic function of the MHC genes?
A
Involvement in mitigating and regulating the
adaptive immune response
3
Q
- Which region does not contain HLA genes but does contain genes that code for complement components?
a. class I
b. class II
c. class III
A
c. class III
4
Q
- Coding regions of genes are called
a. exons
b. introns
c. polyons
d. none of the above
A
a. exons
5
Q
- True or false? The class I and class II molecules are codominantly expressed but have different tissue distributions.
A
True
6
Q
- True or false? Class I molecules can only be found on
nucleated cells.
A
False
7
Q
- HLA-DR, HLA-DQ, and HLA-DP are which type of
molecules?
a. class I
b. class II
c. class III
d. class IV
A
b. class II
8
Q
- Closely linked genes are inherited as a block which is
known as a:
a. polytype
b. haplotype
c. diplotype
d. triplotype
A
b. haplotype
9
Q
- True or false? A child is haploidentical to each parent
and only siblings may have a 25% chance of being
genotypically identical to each other.
A
True
10
Q
- Define linkage disequilibrium
A
Genes occur more frequently together than expected by chance
11
Q
- Define epitope.
A
An antigenic determinant, the minimum structure
unit with six to seven amino acids that can be perceived as foreign by T- or B-cell receptors
12
Q
- What is the tissue source for DNA-based typing?
A
Nucleated cells
13
Q
- Why is quality control particularly important in the HLA
laboratory?
A
Avoid contamination
14
Q
- What two blood group systems are the major barriers to
transplantation?
A
ABO, HLA
15
Q
- Most immunologic refractoriness to platelets results from
antibodies to:
a. HLA class I antigens
b. HLA class II antigens
c. HLA class III antigens
d. ABO antigens
A
a. HLA class I antigens
