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cardio HTA > HTA inhib canaux Ca2+ info > Flashcards

HTA inhib canaux Ca2+ info Flashcards

1
Q

mécanisme

A

fixe VOC Ca2+ = inhibition
diminue contraction = diminue DC

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2
Q

PDYN

A

coeur : VOC Ca2+ type L sur
tissu nodal = ralenti dépolarisation diastolique
myocarde : isotrope -

vaisseaux : vasodilatation = diminue RPV = diminue PA

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3
Q

indications

A

HTA
prévention crise d’angor
maladie de Raynaud
Tachycardies

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4
Q

PKIN

A

biodisponibilité moyenne en orale : bcp EPPh
métabo par CYP450 3A4/5
cardio dominant = inhibiteur 3A4/5
DHP : vasodilatation

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5
Q

effets indésirables

A

nifédipine : hyperplasie gingivale
verapamil : constipation

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6
Q

interactions

A

PDYN : vasodilatation, chrono, isotrope - (B-bloquant), dromo-

PKIN : inducteurs enzymatique, inhibiteur CYP450 3A4/5, médoc métabolisme par CYP450

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cardio HTA (25 decks)

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