HTA antagoniste R A1 adré info Flashcards

1
Q

mécanisme

A

vaisseaux : diminue vasoconstriction = diminue RPV = diminue PA
vessie : facilité évacuation
SNC : sédatif si passe BHE (liposoluble)

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2
Q

indications

A

HTA, pas 1ère intention (si échec bi-thérapie)

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3
Q

PKIN

A

distribution : prazosine passe pasBHE
métabo par CYP3A4

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4
Q

effets indésirable

A

hypotension orthostatique + tachycardie
vertiges, céphalées
lipothymie

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5
Q

contre-indication

A

hypotension
insuffisance hépatique sévère

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6
Q

interactions

A

neuroleptique
anti-dépresseur
vasodilatateurs

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