HSC - Biology Flashcards
Life
An adaptable self-replicating, energy-dependant system
A-sexual
Produces identical offspring
- Vegetation propagation
- Spores
- Budding
- Binary Regeneration
- Fragmentation regeneration
Sexual (gambetes)
Involves combining genetic material from two parents
External (aquatic)
- Large number of offspring
- high mortality
- Low investment (energy)
- Random combination of gametes
Internal (terrestrial)
- Small number of offspring
- Low mortality
- High investment
- Selection of best gamete combination (courtship)
Hormone reproduction in Humans
Oestrogen = Causes eggs to mature in ovaries once a girl hits puberty Testosterone = Stimulates sperm production in males
Hormones
Follicle Stiimulating hormone (FSH)
- Causing maturation of an egg in the ovary
Progesterone
- Involved in maintaining the uterus linings
Luteinising hormone
- Stimulates the release of the egg
Binary Fission
A-sexual reproduction by a separation of the body into two new bodies
- A organism duplicates its genetic material or DNA, and then divides into two parts with each new organism receiving one copy of DNA
Eukaryotic Binary Fission
Occurs when a single protist divides its nucleus and then separates into two seperate organisms
Prokaryote binary fission
The DNA molecule replicates, then attaches each copy to a different part of the cell membrane. When the cell pulls apart, they replicate and original
Fragmentation
When an organism splits into fragments, and each fragment grows into individual organisms which are clone of the original
Budding
A form of a-sexual reproduction in which a new individual develops from some generative anatomical point of the parent organism. In some species buds may be produced from almost any point of the body, but in many cases budding is restricted to specialised areas
Gametes
An organism’s reproductive cells
Zygote
The union of the sperm cell and the egg cell. Begins as a single cell but divides rapidly in the days following fertilisation
Eutherians
One of two mammalian with extent members the diverged in early cretaceous or perhaps the late Jurassic. Give birth to well developed young
Deoxyribic Nucleic Acid (DNA)
A macro molecule made of Carbon, Hydrogen, Oxygen, Nitrogen and Phosphorous combined into units called nucleotides
The DNA Story
Darwin - Theory of evolution but no mechanism
Boveri + Sutton - Darwin’s mechanism might be visible structures in cells that can be seen using chemicals
Crick + Watson - Nobel prize for describing the DNA molecule
- chemical analysis of DNA
- used x-ray crystallography images taken by Rosalind Franklin without her knowledge
Mitosis
Cell division for growth/repair
Produces 2 identical daughter cells
- To form a new individual all cells perform mitosis byt when differentiation into tissue types si complete most cells stop doing mitosis
- Epithetical cells continue to divide (skin, digestive track…)
Meiosis
Type of cell division of germ cells in sexually-reproducing organisms used to produce the gametes, such as sperm or egg cells. It involves two rounds of division that ultimately result in four cells with only one copy of each chromosome.
Artificial Insemination
Deliberate introduction of sperm into a females cervix for the purpose of achieving pregnancy without sexual intercourse
Sources of variation
1) Crossing over of homologous pairs
2) Random assortment of homologous pairs
3) Random recombination of gametes
4) Mutation - (copying errors, mutations
Clone
A genetically identical copy of a biological entity
- Scientist take a somatic cell from animal they wish to replicate
- Somatic cell nuclear transfer (removal of nucleus from egg. create inoculated egg)
- Fusion of DNA into gamete (through electrical fusion or injections)
- The egg develops before being implanted into womb
Polypeptide/protein synthesis
- Unzipping: Enzyme RNA polymerase opens up the DNA
- Transcription: DNA is transcribed to become RNA (uracil replace thymine). Makes an mRNA strand
- Translation: mRNA moves to a ribosome and molecules of tRNA bring amino acids to the ribosome in the correct sequence. (Codon holds the three together)
- Polypeptide Synthesis: Amino acids are joined by peptide bonds to form polypeptide chain
- Fold for protein assembly
Groups of 3 mRNA bases are called Codons
Groups of 3 tRNA bases are called Anti-Codons
Inheritance
Transfer of DNA from one generation to another
Allele
Different versions of the same gene
- in most cases genes have two alleles however there can be multiple alleles (blood types)
Dominant allele
always expressed
recessive allele
only expressed if there are no dominant alleles
Heterozygous
Has 2 different alleles for a particular gene
Homozygous (dominant/recessive)
has 2 identical alleles for a particular gene
Chromosomes
A DNA molecule made from protein and deoxyribonucleic acid, humans have 23 pairs
Y = male X = Female
Types of chromosomes:
1) Sex chromosomes = code for sexual characteristics (breasts, adam apple) - humans have 2 chromosomes (XX = female, YX = Male) *these are haploud
2) Autosome = Don’t code for sexual characteristics (eye colour) - humans have 22 pairs *these are diploid
Autosomal inheritance
Patterns in expression of characteristics which are found on autosomes
- Dominant / recessive
- Co-dominant = both alleles are expressed in genotype (both expressed)
- Incomplete = The dominant allele is only partly expressed (mixed)
Pedigrees
Shows how traits are passed on over many generations
circle = female
Square = male
filled in = carrying the trait
*if almost all the affected individuals are males its probably sex linked and if even than autosomal
Phenotypic, genotypic and allele frequency
Phenotype = An organism’s physical expression of a particular characteristic
The expression of trait
Genotype = An organism’s genetic makeup for a particular characteristic.
The alleles for a trait
Allele = The relative proportion of a particular allele in a population
Total number of alleles in the population / Number of an allele in a population
Mutagen
An agent that causes mutation
1) Electromagnetic Radiation
- High energy EM radiation causes atoms to vibrate and lose electrons. Breaks bonds
2) Chemical
- Incorporate themselves into DNA
- Insert themselves into DNA
- Make gaps in DNA
3) Biological
- Mutagenic chemicals which come from microbes, plants and animals
Cancer
Cells replicate incorrectly
Radiation
Electro-magnetic radiation (EMR)
- Spectrum
- Radiowaves (gamma -> radiation)
Chemical
Compounds that interfere with DNA (replaces part of it)
Biological
Natural compounds that can cause damage
Point Mutations
One nucleotide is changed
Occur due to errors in DNA replication (sometimes mutagens
1) Insertion = extra nucleotide added
Every codon after the mutation is effected. (frameshift point mutations) large effect
2) Deletion = nucleotide not included
Every codon after the mutation is effected. (frameshift point mutations) large effect
3) Substitution = wrong nucleotide added
Mis-sense = substitution of one nucleotide so the codon codes for a different amino acid
Non-sense = substitution of one codon so that the codon is a stop codon
Silent = substitution of one nucleotide, so the codon codes for the same amino acid
*sickle cell anaemia is an example
Chromosomal mutations
A change in the arrangement or structure of a chromosome
- They occur due to errors in cell division -> often when crossing over in meiosis
1) Deletion = A section breaks off and is lost
2) Inversion = A section breaks off, flips around and reattaches
3) Translocation = A section breaks off and sticks to a different chromosome.
4) Duplication = A section is accidentally copied more than once
5) Non-disjunction = Chromosome don’t seperate properly
* if breakage occurs in the middle of a gene, the gene will be destroyed
- Down syndrome (trisomy 21) = genetic disorder where people have 3 copies of chromosome 21
Germ cell
Any cell which can divide (meiosis) to form sex cells
Germ-line mutations
A change in the DNA of a germ cell parent -> offspring - all of the offsprings cells will have the mutation *parent is unaffected (down syndrome)
Somatic cell
Any cell which forms the body tissue of the organism (mitosis)
Somatic mutation
A change in the DNA of a somatic cell
- will only affect daughter cells and offspring is unaffected
(lung cancer)
Coding DNA
DNA which codes for the amino acid sequence of a protein
EFFECT
- Vary depending on type of mutation and what cell its in
(Sickle cell anaemia)
Non-coding DNA
DNA which doesn’t code for proteins
EFFECT
- Makes functional RNA: change in efficiency of protein synthesis
- Regulatory sequences: change in amount of protein produced
- Repetitive sequences: none
(lung cancer
Gene pool
Total collection of alleles for all genes in a population
- Retain the genetic information of the population
- Used to compare populations
- Are dynamic
Changes in Gene pools
1) Gene flow = movement of alleles between populations, and can cause changes in allele frequency
2) Genetic drift = random events occurring within the population, can lead to changes in allele frequency
3) Mutation = change in an organism’s DNA and acts as a source of new alleles
4) Selection pressures = external factors which affect an organism’s ability to survive
- positive selection pressure: increase allele frequency
- visa versa
Biotechnology
The use of biological systems, processes and organisms in the creation of new products and technologies.
1) industrial biotechnology
2) Agriculture biotechnology
3) Reproductive technology