H.Pylori and gastric disease Flashcards
what are the non-invasive diagnostic tests for H.Pylori ?
serology IgG
urea breath test
stool antigen
what are the invasive diagnostic tests for H.Pylori ?
histology
culture
rapid slide urease test
what is the eradication therapy for H.Pylori ?
triple therapy for 7 days
clarithrommycin 500mg bd
amoxycillin 1g bd (metronidazole 400mg bd) - tetracycline if penicillin allergy
PPI - omeprazole 20mg bd
what are symptoms of a peptic ulcer ?
epigastric pain - can be only sign nocturnal/hunger pain - common in DU back pain nausea +/- vomiting weight loss, anorexia possible haematemesis/melaena
how is a peptic ulcer treated ?
PPI - omeprazole
what are complications of a peptic ulcer ?
acute bleeding chronic bleeding perforation fibrotic stricture gastric outlet obstruction
what are clinical features of gastric outlet obstruction ?
vomiting, lacks bile, fermented foods early satiety, distension weight loss gastric splash dehydration and loss of H and Cl
what is found on bloods of gastric outlet obstruction ?
metabolic alkalosis low Cl low Na low K renal impairment
how is gastric outlet obstruction diagnosed ?
UGIE
how is gastric outlet obstruction treated ?
endoscopic balloon dilatation
surgery
how does gastric cancer present ?
dyspepsia early satiety nausea and vomiting weight loss GI bleeding iron deficiency anaemia gastric outlet obstruction
what causes gastric cancer ?
diet
smoking
H.Pylori
genetics - mostly sporadic
how is gastric cancer diagnosed ?
endoscopy and biopsy
staging - CT
how is gastric cancer treated ?
surgical resection
chemotherapy
