How the brain goes wrong Flashcards
1. Understand the approach to neurological diagnosis, from localisation to pathophysiology 2. Acquire basic knowledge of the range of disease processes that can affect the brain using a 'surgical sieve' approach 3. Understand key terminology relating to neurological disease 4. Be familiar with the range of investigations used in neurological disease
Where do a lot of nerves comes together
Brachial plexus
Days to weeks disease course
Sub acute e.g inflammatory, infections
Sudden disease course
Acute eg vascular or trauma
Months and months disease course
Endocrine, metabolic, inflammation eg
Paroxysmal
Up and down attacks eg epilepsy
Example of hard neurological signs in the CNS
Unilateral extensor plantar response big toe when normal toe goes down
Thalamus
Where is the lesion? Unable to form new memories, immediate recall intact
Hippocampus or medial temporal lobe
Argyll Robertson pupil
No constriction using a light but constriction when accommodating. Response is specifically related to syphilis
Tremor, rigidity and bradykinesia is called what
An akinetic rigidity syndrome. These clinical features tell us the disease is in the basal ganglia (deep grey matter)
Risperidone for schizophrenia
Block dopamine receptors in the nigrostriatal pathway
