Host defense overview Flashcards
1
Q
which immunoglobin is important in the lungs?
A
IgA
2
Q
What happens when PAMPs and DAMPS are recognised?
A
The cells produce interferons and a wave of infromation is spread out: TYPE I/III: a/b/gamma -activates NK cells -upregulates MHC, Mx proteins -activates RNase L, PKR (protein kinase R) -induces anti-viral state TYPE II: IFNgamma - proinflammatory - Th1 cytokine - “immune interferon”
3
Q
What is the order of immunoglobulin responding?
A
- IgM is the first to respond
- IgG response persists.
4
Q
What are the defences against bacteria?
A
- surface defences
- antibody opsonisation
- complement- causing lysis/opsonisation
- phagocytosis
- release of inflammatory mediators and acute phase proteins
- fever
5
Q
What are the defences against viruses?
A
- surface defences
- interferons- VERY IMPORTANT AGAINST VIRUSES
- inflammatory mediators and acute phase proteins
- NK cells
- Antibody, complement, ADCC ( antibody dependant cell-mediated cytotoxicity)
- T cells
6
Q
What are the mucosal defences?
A
- Mannan binding proteins
- Antimicrobial peptides
- enzymes e.g. lysozyme
- mucosal lymphocytes
- secretory IgA
7
Q
Which infectious disease of childhood that doesn’t have a vaccine
A
RSV ( respiratory syncytial virus
