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PID > Host Defense > Flashcards

Host Defense Flashcards

1
Q

What is innate immunity?

A

complement pathways

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2
Q

What is adaptive immunity?

A

primary and secondary humoral immune response, antibody, response is specific for the antigen and memory is generated

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3
Q

What does C1 binding to C-reactive protein on the pathogen surface activate?

A

the classical pathway of complement factors

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4
Q

What is the classical complement pathway?

A

Antibody + Antigen

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5
Q

What is the route of the classical pathway?

A

Activated by binding of antibody to antigen, C1 reactive protein binding, inital complement component- C1q. C1r, C1s, C4, C2

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6
Q

What is C3 convertase?

A

C4bC2b

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7
Q

What is C5 convertase?

A

C4bC2bC3b

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8
Q

What is the route of the lectin pathway?

A

Activated by mannan binding lectin (MBL), MBL-assoicated serine protease-2 (MASP-2), initial complement component- C4, C2

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9
Q

What is the route of the alternative pathway?

A

Activated by contact of microbial cell wall with C3, initial complement component-C3, Factor B, Factor D and properdin

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10
Q

What does MAC cause?

A

lysis

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11
Q

What does C3b cause?

A

opsonization

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12
Q

What does C3a and C5a cause?

A

activation of inflammatory response

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13
Q

What is humoral immunity?

A

antibodies secreted by antigen-activated B cels and their plasma cells

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14
Q

What is secondary humoral response?

A

shorter lag phase, greater magntiude

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15
Q

What does Ig stand for?

A

Immunoglobulin

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16
Q

What are epitopes?

A

Antigen determinants

17
Q

What are paratopes?

A

the part of an antibody which recognize an antigen, the antigen binding site of an antibody

18
Q

What two parts does an antibody have?

A

Fc (bottom) and Fab 2(top)

19
Q

T or F: B-cell receptors and antibodies recognize native protein antigens?

A

True

20
Q

What is MHC?

A

Major histocompatiblity complex

21
Q

What do CD8 and T cells function as?

A

cytotoxic T lymphocytes

22
Q

What is cell mediated immunity?

A

antigen-activated T cells and the cytokines they create

23
Q

What do TCRs recognize?

A

Ag on MHC

24
Q

What are the two classes of MHC proteins?

A

MHC I & II

25
Q

What does MHC I distribute, function and result?

A

nucleated cells
cytotoxic T cells to Ag
T cell mediated toxicity

26
Q

What does MHC II distribute, function and result?

A

B cells and macrophages
T helper cell to Ag
T cell mediated help

27
Q

T or F: MHC II can activate macrophages and B cells

A

True

28
Q

What are APC’s?

A

macrophages, dendrites and B cells

29
Q

T or F: APC’s must contact with MHC II

A

True

30
Q

T or F: CD8 T cells are MHC I restricted ?

A

True

31
Q

T or F: CD4 T cells are MHC II restricted?

A

True

32
Q

What is ADCC?

A

antibody dependent cell mediated cytotoxicity

33
Q

T or F: ADCC is a response to kill helminths?

A

True

PID (3 decks)

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