Host Defense Flashcards
What is innate immunity?
complement pathways
What is adaptive immunity?
primary and secondary humoral immune response, antibody, response is specific for the antigen and memory is generated
What does C1 binding to C-reactive protein on the pathogen surface activate?
the classical pathway of complement factors
What is the classical complement pathway?
Antibody + Antigen
What is the route of the classical pathway?
Activated by binding of antibody to antigen, C1 reactive protein binding, inital complement component- C1q. C1r, C1s, C4, C2
What is C3 convertase?
C4bC2b
What is C5 convertase?
C4bC2bC3b
What is the route of the lectin pathway?
Activated by mannan binding lectin (MBL), MBL-assoicated serine protease-2 (MASP-2), initial complement component- C4, C2
What is the route of the alternative pathway?
Activated by contact of microbial cell wall with C3, initial complement component-C3, Factor B, Factor D and properdin
What does MAC cause?
lysis
What does C3b cause?
opsonization
What does C3a and C5a cause?
activation of inflammatory response
What is humoral immunity?
antibodies secreted by antigen-activated B cels and their plasma cells
What is secondary humoral response?
shorter lag phase, greater magntiude
What does Ig stand for?
Immunoglobulin
What are epitopes?
Antigen determinants
What are paratopes?
the part of an antibody which recognize an antigen, the antigen binding site of an antibody
What two parts does an antibody have?
Fc (bottom) and Fab 2(top)
T or F: B-cell receptors and antibodies recognize native protein antigens?
True
What is MHC?
Major histocompatiblity complex
What do CD8 and T cells function as?
cytotoxic T lymphocytes
What is cell mediated immunity?
antigen-activated T cells and the cytokines they create
What do TCRs recognize?
Ag on MHC
What are the two classes of MHC proteins?
MHC I & II
What does MHC I distribute, function and result?
nucleated cells
cytotoxic T cells to Ag
T cell mediated toxicity
What does MHC II distribute, function and result?
B cells and macrophages
T helper cell to Ag
T cell mediated help
T or F: MHC II can activate macrophages and B cells
True
What are APC’s?
macrophages, dendrites and B cells
T or F: APC’s must contact with MHC II
True
T or F: CD8 T cells are MHC I restricted ?
True
T or F: CD4 T cells are MHC II restricted?
True
What is ADCC?
antibody dependent cell mediated cytotoxicity
T or F: ADCC is a response to kill helminths?
True
