Hormones - Chapter 2 Flashcards
Exocrine glands
gland that secretes into a duct that carries the secretion to the surface of the body cavities.
Endocrine glands
a gland that secretes hormones directly into adjacent tissue; also called a ductless gland
Hormones
a chemical that is secreted by an endocrine gland and that affects the functioning of a cell or organ; often carries into bloodstream.
Steroid hormones
(oestrogen, progesterone, cortisol + aldosterone) - lipid soluble
hormones bind to transport proteins, enabling them to travel in blood
once target cell is reached, it separates from transport protein and diffuses across cell membrane
combines with receptor protein inside cytoplasm/nucleus
hormone-receptor complex activates the genes controlling the formation of particular proteins - by binding to promoter section of gene, stimulating/inhibiting transcription
Protein/Amine hormones
- water soluble
unable to diffuse across cell membrane
attaches to receptor proteins in membrane of target cell
combination of hormone and receptor causes secondary messenger substance to diffuse through cell and activate particular enzymes
Enzyme amplification
a series of chemical reactions in which the product of one step is an enzyme that produces an even greater number of product molecules at the next step (one hormone molecule activates thousands).
Hormone clearance
- hormones being turned off - done by breaking down the hormone molecules
- some broken down in target cells - most broken down in liver/kidneys
- degraded hormones excreted in bile/urine
Hypothalamus
part of the brain lying just below the thalamus and above the pituitary gland; controls many homeostatic mechanisms, such as body temperature, water balance and heart rate.
Releasing factors
stimulate the secretion of a hormone
Inhibiting factors
slow down the secretion of a hormone
Pituitary gland
and endocrine gland located below the brain; joined to the hypothalamus by a stalk called the infundibulum.
Anterior lobe of pituitary gland
(front) connected to the hypothalamus by a complex network of blood vessels lying in the infundibulum.
Posterior lobe of pituitary gland
(rear) joined to the hypothalamus by nerve fibres that come from the hypothalamus and pass through the infundibulum to the posterior lobe.
Secretions of Anterior lobe
- gonadotropins
- growth hormone
- thyroid stimulating hormone
- adrenocorticotropic hormone
- prolactin
Secretions of Posterior lobe
- oxytocin
- antidiuretic hormone