Homeostasis blood sugar + temp - Chapter 5 Flashcards
Homeostasis
process whereby body’s internal environment is maintained in a steady state.
Properties of tissue fluid maintained by homeostasis:
- core body temperature (normal range 37ºC)
- pH and concentration of dissolved substances in body fluids
- fluid concentrations
- concentration of nutrients, metabolic waste and gases
Tolerance limits
conditions which body can function - if conditions change beyond tolerance limits the body systems don’t function properly.
- blood pressure 120/180mm Hg
- blood glucose 3.5-8mmol/L
Feedback systems
a circular situation in which body responds to change or stimulus
negative - response decreases original stimulus
positive - response increases original stimulus
Feedback loop
involves a stimulus, receptor, modulator, effector, response and feedback
Role of the liver
- largest gland in the body, and involved in blood glucose regulation
- converts glucose to glycogen for storage (glycogenesis)
- converts glycogen to glucose for release (glycogenolysis)
- most of livers blood supply comes from the hepatic portal vein which carries blood from the stomach, spleen, pancreas and intestines
Glycogenesis
glucose –> glycogen
Glycogenolysis
glycogen –> glucose
(breakdown of glycogen)
Gluconeogenesis
fats/proteins –> glucose
Role of the pancreas
- is an endocrine and exocrine gland
- contains clusters of hormone secreting cells called islets of langerhans
Alpha cells
secrete glucagon
Beta cells
secrete insulin
Role of the adrenal glands
- situated above the kidneys
- composed of an adrenal medulla and an adrenal cortex
(outer) cortex - cortisol [sstimulates conversion of glycogen to glucose, stimulate movement of amino acids from cells to liver, and some may be converted to glucose]
(inner) medulla - noradrenaline/adrenaline [breakdown of glycogen to glucose, stimulates production of lactic acid from glycogen which is then used to form glucose]
Glands involved in glucose regulation
- liver
- pancreas
- adrenal glands
Optimum core body temperature
36.8ºC
- this temp is achieved when heat lost = heat gained (thermoregulation maintains this)