Hormones Flashcards
What are androgenic-anabolic steroids?
Synthetic drugs that mimic the effects of testosterone.
Androgenic refers the the masculinizing effect.
Anabolic refers to the building effect.
What is endocrine signaling?
It is the effect that hormones have on different parts of the body when they are released by endocrine glands to various and distant receptor cells.
What are the glands in the endocrine system?
Hypothalamus, pituitary, thyroid, adrenal, testes (male) / ovaries (female)
What are the different types of hormones?
Intracrine - affects the cell that synthesized it
Autocrine - attached to the cell that synthesized it and regulates its function
Paracrine - affects neighboring cells
Exocrine - affects organisms outside the body
Endocrine - affects cells in distant parts of the body
How does the hypothalamus and pituitary gland control hormone release?
- Oxytocin and vasopressin are released by the neurosecretory glands in the hypothalamus to the posterior pituitary.
- Neurosecretory glands also synthesize releasing and inhibiting hormones, and release them into the hypophyseal portal system.
- The anterior pituitary then acts in accordance to the releasing and inhibiting hormones; releasing various hormones.
How are steroids hormones produced and work?
- Synthesized from cholesterol and produced in adrenal glands and testes/ovaries.
- They are able to cross cell membranes and will trigger DNA to produce proteins.
How are nonsteroid hormones produced and work?
- They are short chain amino acids, also known as peptides.
2. They do not cross the cell membrane and work through a second messenger cascade.
What does vasopressin (Anti-Diuretic Hormone - ADH) do?
Regulates function of kidneys to balance the level of salt in blood plasma. When the blood is Hypertonic, there is too much salt.
What does Oxytocin do?
It is involved with reproductive functions.
- It triggers contractions of the uterus.
- It triggers the release of milk in the breast.
What does the Thyroid-Stimulating Hormone (TSH) do?
It stimulates the thyroid gland to release thyroxine. Thyroxine is crucial for regulating metabolism, muscle control and brain development.
What does the Adrenocorticotropic Hormone (ACTH) do?
- This hormone is central to the stress response.
- The stress response is activated through the hypothalamic-pituitary-adrenal (HPA) axis.
- When stressed, the hypothalamus releases corticotropin-releasing hormone (CRH) to the anterior pituitary which then releases ACTH.
- When ACTH binds to the adrenal glands, cortisol is released, regulating the fight or flight response.
What does Prolactin do?
It stimulates the production of milk in the mammary glands.
What does Growth hormone do?
It stimulates growth of all tissues in the body and is especially important at puberty.
With aging, a drop in GH results in loss of muscle mass, increased body fat, thinning of skin and loss of cardiovascular function.
What so Gonadotropic hormones do?
It stimulates production of estrogen and testosterone.
What are the 2 main hormones of the posterior pituitary gland?
- Vasopressin
2. Oxytocin