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Endocrinology > Hormone Receptors > Flashcards

Hormone Receptors Flashcards

1
Q

IntRAcellular Signalling

A

communication within a Cell

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2
Q

IntERcellular Singallin

A

Communication between different cells

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3
Q

Ligand

A

Any molecule/protein that binds to a specific site on a protein or any other molecule e.g. hormone-receptor

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4
Q

Receptor

A

A molecule that recognises and binds to a ligand with high specificity

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5
Q

What is the difference between AFFINITY and AVIDITY?

A

Affinity is the strength, Avidity is the total strength of interaction that has several binding sites.

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6
Q

What hormone are secreted by the Hypothalamus?

A 
Thyrotropin-Releasing hormone
Somatostatin
Gonadotrophin-releasing hormone
Corticotrophin-releasing hormone
Growth hormone releasing Factor
Prolactin inhibiting factor (dopamine)
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7
Q

What hormones are secreted by the Anterior Pituitary?

A 
TSH
Luteinizing Hormone
Folic-stimulating Hormone
Growth Hormone
Prolactin
Adrenocorticotropin
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8
Q

What hormones are secreted by the Posterior pituitary?

A

Vasopressin

Oxytocin

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9
Q

What hormones are secreted by the thyroid?

A

Thyroxine and triiodothyronine

Calcitonin

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10
Q

What hormone is secreted by the Parathyroid?

A

Parathyroidhormone

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11
Q

What hormone is secreted by the adrenal cortex?

A

Aldosterone and Cortisol

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12
Q

What hormones are secreted by the Adrenal medulla?

A

Adrenaline and noradrenaline

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13
Q

What hormones are secreted by the Ovary?

A

Oestrogen and Progesterone

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14
Q

What hormone is secreted by the testis?

A

Testosterone

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15
Q

Intracellular Receptors

A
  • act directly on the control of gene expression
  • small hydrophobic hormones
  • carried by plasma proteins
  • diffuse across plasma membrane
  • intracellular receptors in cytoplasm/nucleus
  • some receptors are cytoplasmic some are nuclear
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16
Q

G Protein Coupled receptors

A

-7 membrane domains
-Interact with intracellular guanine nucleotide binding proteins
-exist for the large and small hormones
EXAMPLES: adrenaline receptor, Glucagon receptor, oxytocin receptor.

17
Q

Enzyme Linked Receptors

A

-Single transmembrane domains
-Cytoplasmic domain has enzymatic activity
EXAMPLES: insulin receptor, platelet derived growth factor receptor, Epidermal growth factor receptor, Growth hormone receptor.

18
Q

Receptor Tyrosine Kinases

A
  • > Hormone binds
  • > Receptor dimerises
  • > dimerised receptor phosphorylate each other on specific tyrosine residues
  • > tyrosine phosphorylation promotes some protein-protein interactions leading to signalling pathways

Endocrinology (12 decks)

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