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Biology > Homepstatis- Paper 2 > Flashcards

Homepstatis- Paper 2 Flashcards

1
Q

Define homeostasis

A

The maintenance of a stable/constant internal environment
The ability to respond to changes and maintain organisms’s cells, tissues and organ systems in a balanced equilibrium around an optimum point of

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2
Q

What is the benefit of maintaining a constant internal environment and why is this important

A

Enzyme controlled biological reactions can take place at a constant optimum rate
Organism that control this are more independent as they have a greater geographical range so can colonise more habitats and ecosystems
Also have a greater chance of finding food, shelter and mates

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3
Q

Control mechanisms pathway

A

Receptors—> sensory neurones—> CNS—> motor neurones—> effectors

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4
Q

Negative feedback definition

A

Negative feedback means that there is an increase/ decrease from the set point, the opposite effect is instigated- produces a response that returns the value to the norm

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5
Q

Positive feedback definition

A

Occurs when a deviation from an optimum causes even greater deviation from the normal

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6
Q

What are endotherms

A

Maintain body temperature by both physiological and behavioural means

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7
Q

What are ectotherms

A

Maintain body temperatures by behavioural means only- exposing themselves to the sun, taking shelter and gaining warmth from the ground.

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8
Q

The temperature control system in endotherms - hot and cold

A

Monitored by receptor in the hypothalamus

Hot:
- a rise in blood temperature is detected by thermo receptors in the heat loss centre
- the heat loss centre sends nerve impulses to the sphincter muscles in the skin arterioles and to the sweat glands. Vasodilation and increased sweating result. The blood is cooled and the core temperature falls.

Cold:
- a fall in blood temperature is detected by thermoreceptors in the heat gain centre
- the heat gain centre stimulates vasoconstriction and shivering. The hairs on the skin are pulled upright.
- thermoreceptors are also found in the skin which will detect a change in skin temperature and send nerve impulses via the autonomic nervous system to the hypothalamus.

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9
Q

Describe how a hormone works

A
  • produced by pancreas glands, which secrete directly into the blood
  • carried in the blood plasma to target cells
  • receptors are complementary shape to the hormone
  • hormones bind to specific receptors only on the target cells which have the complementary receptor
    -they are effective in small quantities but often widespread and have long lasting effects
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10
Q

Describe the pathway of blood glucose regulation

A

Islets of langerhans- beta cells- capillaries into which hormones are secreted- pancreas has glucose receptor cells which control glucose concentration

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11
Q

What is the range for blood glucose concentration

A

80-100mg 100cm-3

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12
Q

Name the classifications of high and low blood glucose concentration

A

Hypoglycaemia- very low levels
Hyperglycaemia- very high levels of

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13
Q

What are the endocrine cells of the pancreas called and what do they secrete specifically - what is their relationship

A

Islets of langerhans
Alpha cells secrete glucagon
Beta cells secrete insulin
They are antagonistic

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14
Q

Describe the process behind insulin secretin

A

Insulin is a peptide hormone and is synthesised and secreted by beta cells in the pancreas
Insulin reduces blood glucose levels to a normal range

  1. Insulin binds to complementary receptors on the cell surface membrane of target cells
  2. This controls the uptake of glucose by regulating the inclusion of glucose carrier proteins in the surface membranes of target cells (striated muscle cells and adipose tissue)
  3. Insulin also activates enzymes hat stimulate the conversion of glucose to glycogen (glycogenesis). this therefore decreases blood glucose

Off spec: GLUT1 channel proteins are found on all cell membranes

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15
Q

Describe the process behind glucagon secretion

A

Synthesised and secreted by alpha cells in the pancreas- aim is to increase blood glucose levels to a normal range

  1. Glucagon binds to receptors on the cell surface membrane of target cells
  2. Activate enzymes involved in the hydrolysis of glycogen to glucose (Glucogenolysis)
  3. Activates enzymes involved in the conversion of glycerol and amino acids into glucose (gluconeogenesis)
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16
Q

Explain the action of glucagon

A
  • works by activating enzymes
  • hydrolysis of glycogen to glucose (Glycogenolysis)
  • gluconeogenesis
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17
Q

Describe the role of glycogen formation and its role in lowering blood glucose levels

A
  • glucose concentration in the cell/liver falls
    -below that in blood
  • creates glucose concentration diffusion gradient
  • glucose enters cell by facilitated diffusion via carrier proteins
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18
Q

Describe how blood glucose levels can be increased using hormones

A
  • release of glucagon from alpha cells
  • leads to the formation of glucose in liver cells
  • from non-carbohydrates
19
Q

Describe what happens after a meal

A
  • glucose is absorbed from the ilium into the hepatic portal vein
  • blood glucose concentration increases, which is detected by the pancreas
  • pancreas secretes insulin from its beta cells
  • insulin causes glucose to be taken up by the liver and converted into glycogen
  • this reduces blood glucose, which is detected by the pancreas which stops secreting insulin
  • if the glucose level falls too far this is detected by the pancreas
  • pancreas now secretes glucagon from its alpha cells
  • glucagon causes the liver to hydrolyse some of its glycogen store to glucose, which diffuses into the blood via facilitated diffusion
  • this increases blood blood glucose and pancreas stops secreting glucagon
20
Q

Describe the second messenger model of hormone action

A

Adrenaline is a hormone released by adrenal glands which also increases blood glucose levels

  1. Adrenaline and glucagon both bind to specific transmembrane protein receptor on the surface of the target cell membrane- they are called the first messenger
  2. A hormone- receptor complex is formed (causing the receptors protein to change tertiary structure)
  3. The hormone receptor complex activates adenylate cyclase (an enzyme inside the cell that results in the conversion of ATP into cyclic AMP that acts as second messenger)
  4. The second messenger causes a series of chemical changes that produce the required rapid response
  5. The CAMP is the second messenger and activates protein kinase enzymes which produce a cascade of chain reactions that catalyse the conversion of glycogen to glucose
21
Q

Glucagon definition

A

Hormone that causes hydrolysis of glycogen to glucose

22
Q

Glycogen definition

A

Energy storage carbohydrate found in liver and muscles

23
Q

Glycogenolysis definition

A

Glycogen hydrolysed to glucose

24
Q

Glycogenesis definition

A

Glucose to glycogen

25
Gluconeogenesis definition
Glucose from amino acids and glycerol
26
What is diabetes caused by
Failure of glucose homeostatis In both types there is a very high blood glucose concentration after a meal so active transport pumps in the proximal convoluted tubule of the kidney can’t reabsorb it all from the kidney filtrate- much of the glucose is excreted in urine
27
Type 1 diabetes
Insulin- dependant diabetes A severe insulin deficiency due to autoimmune killing of beta cells either caused by a virus or faulty gene
28
Type 2 diabetes
Non-insulin dependant diabetes Insulin is produced but the insulin receptors in the target cells are unresponsive, so insulin has no effect This is sometimes described as having a lack of sensitivity to insulin
29
Type 3 diabetes off spec
Gestational diabetes
30
Symptoms of diabetes
High thirst due to osmosis of water from cells to the blood, which has a low water potential Large volumes of urine production due to excess water in the blood Poor vision due to osmotic loss of water from the eye lens Tiredness due to loss of glucose in urine and poor uptake of glucose by liver and muscle cells Muscle wasting dye to gluconeogenesis caused by increased glucagon
31
What are the three basic functions of the kidney
1. Forms glomerular filtrate through ultrafiltration 2. Reabsorption of glucose and water through proximal convoluted tubule 3. Osmoregulation- maintaining concentration gradient in the medulla by the loop of Henle
32
What is a fibrous capsule
An outer membrane that protects the kidneys
33
What is a cortex
A lighter coloured outer region made up of renal capsules, convoluted tubules and blood vessels
34
What is a medulla
A darker coloured inner region made up of loops of henle, collecting ducts and blood vessels
35
What is a renal pelvis
A funnel shaped cavity that collects urine into the ureter
36
What is a ureter
A tube that carries urine to the bladder
37
What is a renal artery
Supplies the kidney with blood from the heart via the aorta
38
What is the renal vein
Returns blood to the heart via the vena cava
39
Describe Osmoregulation
Osmoreceptors in the hypothalamus of the brain detect the fall in water potential ADH is secreted into the capillaries by the posterior pituitary gland ADH travels to kidneys in blood and increases the permeability of the cells of the distal convoluted tubule and collecting duct to water ADH works by causing vesicles found with aquaporin proteins,to fuse with the cell surface membranes of cells of the distal convoluted tubule and collecting duct
40
The formation of glomerular filtrate
Blood enters the kidney through the renal artery, which branches into one million tiny arterioles, each of which enters a renal capsule Affront arteriole is wider, efferent arteriole is narrower- creating a high hydrostatic pressure Ultrafiltration of small molecules, urea, water, mineral ions pass through basement membranes, acting as a filter Blood cells and proteins are too large so stay behind Fluid travels through fenestrations in capillary walls then through podocytes into bowman’s capsule
41
What can’t be passed through fenestrations, provide small facts about the filtrate
Blood cells and large plasma cannot pass through Filtrate can pass out of the glomerulus due to the holes of the capillaries, through the connective tissue and through the spaces between the branches of the podocytes- nearly 85% of filtrate is reabsorbed back into the blood
42
Maintaining a gradient of sodium ions in the medulla by the loop of Henle
Descending limb is narrow and highly permeable to water Ascending limb is wider and impermeable to water Na+ actively transported out for ascending arm, impermeable to water, using ATP and into interstitial fluid, which lowers the water potential Water moves out of descending limb, permeable to water and into blood capillaries by osmosis. Water potential decreases further down the medulla, urea is concentrated in the filtrate
43
The reabsorption of glucose and water by the proximal convoluted tubule
- Na+ actively transported out of the cell lining the PCT and into the blood - creates a concentration gradient of Na+ between the lumen of the PCTand the cell lining the PCT - Na+ diffuses into cell from the lumen of the PCT through the same protein by facilitated diffusion (Co-transport) - glucose moves into cell from the lumen of the PCT against its concentration gradient - glucose diffuses into blood, glucose removed from filtrate
44
Reabsorption of water by the distal convoluted tubule and the collecting ducts
Distal convoluted tubule: Makes final adjustments Reabsorbed water and salts Changes permeability pf wall Collecting duct: Lower water potential down the medulla Water moves out collecting duct via osmosis Water then reabsorbed into the blood, everything left in the collecting duct becomes urine Permeability can change

Biology (21 decks)

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