Homeostasis Flashcards
Homeostasis
Maintenance of constant internal environment irrespective of changes in the external environment
Keeps set point within narrow limits
Negative feedback mechanism
Restoration of norm or set point
Stimulus
Internal or external change in environment away from set point
Receptors
Cells or tissues that detects a stimuli
Coordinating center
Tissues which receives messages from receptors and determines appropriate response
Effectors
Tissues organs which receives message from coordinating center and carry out corrective response
Response
Reaction carried out by effector
Negative feedback
Fluctuates around norm or set point
Corrective actions
Positive vs negative
Positive: reinforces
Uncommon
Intensifies
Labour pain
Negative: counteracts
Common
Maintains homeostasis
Blood glucose concentration
Excretion
Removal of unwanted productS of metabolism
Toxic, poisonous, damage tissues
Main excretory products
. Carbon dioxide:
From aerobic respiration
Through blood stream
. Urea:
Produced in liver
From excess amino acid
Via kidney
. Creatinine:
Energy store in muscle
. Uric acid:
From excess purines
Deamination
Removal of amine group and h aTom from amino acid
Produces ammonia (NH3)
Toxic if allowed to accumulate
Urea cycle ( ornithine cycle)
NH3 + carbon dioxide → urea
Urea excreted through kidneys
Blood vessels in kidney
Renal artery (in)
Renal vein (out)
Ureter
Brings urine out from kidney to urinary bladder
Urethra
Takes urine out from urinary bladder
Capsule
Tough, protective layer
3 major regions of kidney
Cortex, medulla, pelvis
Nephrons
Structural and functional unit of kidneys
Tiny tube like structures in cortex and medulla
Structure of nephron
I) bowman’s capsule @ cortex
Ii) proximal convoluted tube @cortex
Iii) loop of hence @ medulla
Iv) distal convoluted tube @ cortex
V) collecting duct @ medulla connected to pelvis
Afferent arteriole
Branches out into tangle of capillaries: glomerulus
Efferent arteriole
Goes into network of capillaries surrounding the rest of nephron
A) nutrients a useful substances from urine can be returned
B) whatever waste that have not been filtered out can enter nephron and be excited via kidney
Mechanism of excretion in kidneys
Ultrafiltration
Selective reabsorption
Ultrafiltration
Filtering of small molecules including urea out of blood
A) glomerular filtrate is produced
B) flows along entire nephron
C) into ureter
Structure of bowman’s capsule wall
Endothelium: with many gaps so that substance can pass through (60-80 nm)
Basement membrane: made of collagen and glycoprotein
Acts as main selective barrier
Epithelial cells (podocytes):
Inner lining of bowman’s capsule
Many finger like projections that forms gaps (filtration slit )