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Cancer Care > Hodgkin's Lymphoma > Flashcards

Hodgkin's Lymphoma Flashcards

1
Q

When does incidence of Hodgkins Lymphoma peak?

A

20-30

Smaller peak in old age

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2
Q

What is Hodgkins Lymphoma associated with?

A

Epstein Barr Virus and CMV

Previous severe glandular fever

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3
Q

What cell is the hallmark of Hodgkins Lymphoma?

A

Reed-Sternberg Cell

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4
Q

Describe the features of a Reed Sternberg Cell

A 
Multi-nucleated
Giant
Malignant
B-Cell Derivatives
On a background of a variety of cells
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5
Q

What is a contiguous disease?

A

Only spreads to adjacent nodes and structures due to the flow of lymph

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6
Q

What are the types of classical Hodgkin’s lymphoma?

A

Nodular Sclerosing - 70%
Mixed Cellularity
Lymphocyte rich
Lymphocyte depleted

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7
Q

Describe Nodular Sclerosing Hodgkins Lymphoma

A

lacunar cells

young women

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8
Q

Describe mixed cellularity Hodgkins Lymphoma

A

+++Reed-Sternberg
lymphocytes, eosinophils, neutrophils, and histiocytes
no fibrotic bands
elderly

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9
Q

Describe lymphocyte rich Hodgkins Lymphoma

A

small lymphocytes

good prognosis

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10
Q

Describe lymphocyte depleted Hodgkins Lymphoma

A

associated with HIV
popcorn cells
worst prognosis

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11
Q

What are popcorn cells?

A

a variant of Reed Sternberg cells also seen in Nodular Lymphocyte Predominant HL

Of B cell lineage and express CD20

Also known as L&H hodgkin cells

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12
Q

What is Nodular Lymphocyte Predominant Hodgkins Lymphoma?

A

A non classical HL which has popcorn cells rather than Reed Sternberg cells

Has a different management

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13
Q

How does Hodgkins Lymphoma present?

A

Painless rubbery lymphadenopathy - esp. cervical
B Symptoms
Itch
Alcohol Induced Lymph node pain
Chest discomfort with cough/SOB - mediastinal involvement

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14
Q

Describe B symptoms of Hodgkins Lymphoma

A

Fever
Night sweats
>10% weight loss in 6months

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15
Q

How is Hodgkins Lymphoma investigated?

A

Excisional node biopsy - definitive diagnosis
CT neck chest abdo pelvis - staging

FBC -normocytic anaemia, thrombocytopenia
Lactate dehydrogenase - prognosis
ESR- prognosis
HIV test

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16
Q

What is average 5 year survival for Hodgkins Lymphoma?

A

81%

17
Q

What are poor prognostic indicators for Hodgkins Lymphoma?

A 
Male
>45
leucocytosis
lymphocytopaenia
low Hb
low albumin
18
Q

Describe the 4 stages of Hodgkins Lymphoma

A

I - single lymph node region
II - >=2 lymph node regions on same side of diaphragm
III - >= 2 lymph node regions on both sides of diaphragm
IV - diffuse disease in extra-lymphatic sites

19
Q

Describe what the suffix to stages mean (with regards to Ann Arbor staging)

A

A - no symptoms
B - fever, night sweats, weight loss
E - extra-nodal disease

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