hld Flashcards
What is the MOA of atorvastatin?
Inhibits HMG-CoA reductase so less cholesterol is produced by liver and liver makes more LDL receptors to pull LDL from the blood.
What are the adverse reactions with HMG-CoA Reductase Inhibitors?
MyopathyRhabdomyolysisHepatotoxicity
When should HMG-CoA reductase inhibitors be taken?
Most are taken at night since that is when the liver produces cholesterol.
What is the MOA of gemfibrozil?
Clearance of VLDLsBreakdown of triglycerides
What are adverse reactions with gembrizol?
DyspepsiaGallstonesMyopathy
What is the MOA of ezetimibe?
Blocks absorption of cholesterol in jejunum
What are adverse reactions with ezetimibe?
HeadacheMyalgia & arthralgiaAbdominal painDiarrhea
MAO of atorvastatin (Lipitor)
Inhibiting HMG-CoA reductaseLess cholesterol is produced by liverLiver makes more LDL receptors More LDL is removed from the bloodNot making as much cholesterol Removing more LDL from the bloodNOT A PERMANENT DROP IN LEVELSNeed to keep taking the drug Stabilize plaque and decrease inflammation
MAO of simvastatin (Zocor)
Inhibiting HMG-CoA reductaseLess cholesterol is produced by liverLiver makes more LDL receptors More LDL is removed from the bloodNot making as much cholesterol Removing more LDL from the bloodNOT A PERMANENT DROP IN LEVELSNeed to keep taking the drug Stabilize plaque and decrease inflammation
MAO of rosuvastatin (Crestor)
Inhibiting HMG-CoA reductaseLess cholesterol is produced by liverLiver makes more LDL receptors More LDL is removed from the bloodNot making as much cholesterol Removing more LDL from the bloodNOT A PERMANENT DROP IN LEVELSNeed to keep taking the drug Stabilize plaque and decrease inflammation
Adverse reactions of atorvastatin, simvastatin, rosuvastatin
-Myopathy-Rhabdomyolysis -Breakdown of muscle fibers-Acute kidney failure-Hepatotoxicity
Other meds used to treat HLD
Bile acid sequestrantscholestyramine (Questran) Niacin Fibric acid derivative (Fibrates)Fish oil
