HLA

Question 1

Behchets

Answer 1

Hla b51
Oral ulcers+ genital ulcers + eye inflammatorion

Question 2

Hla b27

Answer 2

general autoimmune - ra, ank spon, reactive arthritis, ibd

Question 3

HLA b8

Answer 3

Addison’s, MG, graves

Question 4

Coeliax

Answer 4

HLA DQ2 + HLA DQ8

Question 5

HLA DR3

Answer 5

Graves and hashimotos

Question 6

Collagen type osteogenesis imperfecta

Answer 6

Type 1

Question 7

Collagen type EDS

Answer 7

Thype 3 (rarely type 5)

Question 8

Collagen type goodpastures

Answer 8

Type 4

Question 9

HLA b 5801

Answer 9

Allopurinol sensitivity (drug reaction + eosinophilia - can go to renal failure)
High risk groups are Thai descent , on diuretics, CKD

Question 10

Hla D4

Answer 10

Feltys syndrome

Question 11

HLA A3

Answer 11

Heamochromatosis

Question 12

HLA B27

Answer 12

ankylosing spondylitis
reactive arthritis
acute anterior uveitis
psoriatic arthritis

Question 13

HLA DR2

Answer 13

Good pastures
Narcolepsy

Question 14

HLA DR3

Answer 14

dermatitis herpetiformis
Sjogren’s syndrome
primary biliary cirrhosis

Question 15

HLA DR4

Answer 15

type 1 diabetes mellitus*
rheumatoid arthritis - in particular the DRB1 gene (DRB104:01 and DRB104:04 hence the association with DR4