HIV - Testing and Clinical Management

Question 1

Describe infection of HIV

Answer 1

First spike 2-3 week - increase HIV load (primary infection)
Reduction CD4 cells as viral dissemination
Increased plasma level HIV
6-12week CD4 recover - drop viral load (Ab)
CD4 levels deplete - viral load remain consistent

Question 2

Problem w/ HIV drugs?

Answer 2

Resistance - even 1/2 missed dose can be issue

Many drug-drug interaction - cause sub therapeutic levels

Question 3

Associated problems w/ HIV

Answer 3

1. Candidiasis
   2 Kaposi’s sacroma - HHV8 (spindle cell on biopsy)
2. Oral hairy leukoplakia - EBV
3. Herpes simplex virus