HIV-related illness, Hepatitis, TB Flashcards
What is PCP? And how does it present?
Pneumocystis carinii pneumonia
An opportunistic FUNGAL infection
Non-productive cough, SOB, desaturating on exertion
What are the classic XR signs of PCP vs TB?
PCP: bilateral fine peri-hilar infiltrates
TB: apical cavitating lesions
What is CD4 count?
What is a normal range?
At what level are patients susceptible to what infections?
CD4 cells are T helper cells, which are directly attacked by the HIV
Normal range is 450 - 1600
Under 200 = susceptible to opportunistic infections like PCP, toxoplasmosis
Under 50 = susceptible to mycobacterium, CMV
What is AIDS?
One a patient has AIDS, they will always have it. True or false?
Presence of AIDS defining illnesses
Not based on CD4 count
False: a patient can present with AIDS, receive HAART and no longer have AIDS
List some AIDS defining illnesses?
PCP TB Mycobacterium avium Candidiasis Cryptosporidosis CMV Herpes zoster Salmonella Toxoplasmosis
Kaposi sarcoma
Cervical cancer
Lymphoma (Burkitt’s)
What blood tests are useful to do for HIV?
When can they be relied upon?
Serological tests: only reliable 1 month post-exposure
Check if HIV+ve
CD4 count
Viral load
These assess how advanced the disease is.
Management of PCP?
Co-trimoxazole
Supportive
Also HIV treatment if they aren’t already on it - HAART
What is HAART?
What percentage compliance is needed for efficacy?
Highly active retroviral therapy
The use of 3 different anti-retroviral drugs which each act on the virus in a different way
95% compliance needed for efficacy
What prophylaxis is used to prevent which infections in HIV patients?
If CD4 count <200
- low dose co-trimoxazole for PCP and toxoplasmosis
If CD4 count <50
- azithromycin for TB
If recurrence of CMV: ganiciclovir
Latent TB should be treated, rifampicin and isoniazid
What types of HAART are there?
Nucleoside reverse transcrpitase inhibitors
How are all the Heps transmitted?
A: faecal oral, often shellfish
B: blood borne, sexual, vertical
C: blood borne, vertical, rarely sexual
D: blood borne (but only if B is present too)
E: faecal oral, often pork
Clinical features of all the Heps?
Fevers Jaundice Nausea + vomiting Abdo pain Diarrhoea Weakness, fatigue Anorexia Dark urine
Natural history of hep A?
Incubation, progression to chronic, immunity etc
Incubation is 2-3 weeks
Self-limiting infection
Only ever acute
100% immunity after
Natural history of hep B?
Incubation, progression to chronic, immunity etc
Incubation 1-6 months
Often self-limiting
Some cases lead to fulminant liver disease
Some cases lead to chronic Hep B
Chronic Hep B leads to cirrhosis and carcinoma
Natural history of hep C?
(Incubation, progression to chronic, immunity etc)
What proportion of Hep C cases lead to end-stage liver disease?
Following infection patients have mild illness they don’t seek help for.
Then infection becomes chronic
Some cases are severe, but these cases are more likely to clear the infection.
Once chronic, 1 in 3 chance of developing end-stage liver disease
What is fulminant liver disease?
Severe liver disease
Natural history of hep D?
Incubation, progression to chronic, immunity etc
Needs Hep B antigens to survive so only found alongside Hep B
D is often the dominant infection
More risk of fibrosis if have B and D
Natural history of hep E?
Incubation, progression to chronic, immunity etc
Usually self-limiting
Fulminant and chronic disease in immunosupressed
Management of Hep A?
What about close contacts?
Supportive, monitor LFTs
Only a tiny % get severe liver failure
Post-exposure prophylaxis for contacts: vaccine and Hep A Ig
Management of Hep B?
What about close contacts?
Supportive in acute infection, no treatment needed unless they plan to get pregnant soon.
Chronic:
- pegylated interferon SC weekly for 48 weeks
- oral tenofovir
You can’t cure Hep B, tx only reduces inflammation and controls viral replication
Post-exposure prophylaxis: vaccine and Hep B Ig
Management of Hep C?
Pegylated interferon alpha SC weekly injection
PLUS
ribavirin PO
For 6 months
OR
Direct acting antiviral drugs
The aim is to cure
Management of Hep D?
As with Hep B
- pegylated interferon SC weekly for 48 weeks
- oral tenofovir
Management of Hep E?
Supportive
Monitor LFTs
How is TB transmitted?
Droplet
Infectious patients cough up huge numbers of mycobacteria which can survive in the environment for ages.