HIV Pharm Flashcards
What drug’s serum levels are increased with ethanol ingestion?
abacavir –> both are metabolized by all dehydrogenase
Didanosine should not be co-administered with drugs that can cause what?
pancreatitis (increases risk of AE)
Pt presents with visual changes, what drug were they on? what other AEs may be present if they were also on stavudine?
Didanosine - retinal changes with optic neuritis in adults on high doses and in kids
Didanosine + stavudine –> lactic acidosis, hepatic steatosis
Hyperpigmentation of palms and soles may be seen with…
emtricitabine use
What drugs are active against HIV and HBV?
tenofovir
emtricitabine
lamivudine
What enhances tenofovir oral absorption?
prodrugs disoproxil and alafenamide
NNRTIs MOA
noncompetitive inhibitors of HIV RT
What NNRTI causes nightmares?
Efavirenz - also insomnia, dizziness, drowsiness, HA, skin rash
What drug is used to prevent transmission of HIV from mother to child?
Nevirapine
Rilpivirine has the unique AE of
high doses are associated with QT prolongation
others include: rash, depression, HA, insomnia, inc serum aminotransferases
Integrase inhibitors all share what suffix?
-gravir
Dolutegravir
Elvitegravir
Raltegravir
What is the role of cobicistat?
CYP3A4 inhibitor –> boosting agent for elvitegravir
What protease inhibitor has the most pronounced inhibitory effects on CPY3A4? which has the least?
most - ritonavir (also a very potent CYP 450 inhibitor)
least - saquinavir
What protease inhibitor is not associated with dyslipidemia and hyperglycemia?
Atazanavir
Darunavir must be co-administered with…
ritonavir and cobicistat
